清开灵雾化吸入对食管/贲门癌术后呼吸功能改善的临床观察

Improvement of Respiratory Function by Atomizing with Qingkailing Injection after Resection of Esophageal Carcinoma or Cardiac Carcinoma

目的:初步研究清开灵注射液雾化吸入对食管/贲门癌术后肺部炎症及呼吸功能的影响,为中医药在胸外科围手术期的应用开辟新的思路。方法:选择句容市人民医院胸外科食管/贲门癌手术患者28例,区组随机分为试验组和对照组两组,试验组术后予清开灵注射液雾化吸入,对照组术后予常规雾化液吸入,观察两组用药后体温、血象、胸片改变;术后动脉血气(PaO2、PaCO2、SaO2);咯痰量、痰液性状。并对数据进行统计分析,探讨清开灵注射液雾化吸入对食管/贲门癌术后呼吸功能的影响。结果:试验组术后2~5天咯痰量较对照组比较差异有显著统计学意义(P<0.01),术后第4、5天痰液性状改善较对照组比较差异有统计学意义(P<0.01,P<0.05);两组间术后发热天数比较(P>0.05),第1、6天白细胞计数比较(P>0.05),第1、6天中性粒细胞百分比比较(P>0.05),第1、6天胸片评分比较(P>0.05),第1、3、6天动脉血气比较(PSaO2>0.05、PPaO2>0.05、PPaCO2>0.05),差异无统计学意义。结论:清开灵注射液雾化吸入,能早期稀释食管/贲门癌术后患者痰液,促进患者排痰,但对术后发热情况、肺部炎症状态的改善以及动脉血气影响未优于对照组。

Objective：To observe the impact of respiratory function and pulmonary inflammation by atomizing with Qingkailing Injection after resection of esophageal carcinoma or cardiac carcinoma, in purpose to expanding the application of traditional Chinese medicine in chest surgery. Methods ： Patients after resection of esophageal carcinoma or cardiac carcinoma were separated randomLy into two groups ： experimental group and comparative group. The former atomized with Qingkailing Injection, and the later atomized with ordinary atomized liquid. After wards, body temperature, hemogram and chest radiography were observed ; the arterial oxygen gas analysis ; the amount of sputum and the character of sputum were measured. Results ： The amount of sputum of the experimental group on 2th^Sth day after operation is different from the comparative group in statistics （ P〈0.01 ）. The character of sputum of the experimental group on 4th and 5th day is different from the comparative group in statistics （P〈0.01 , P〈0.05 ）.The comparisons of days of fever （ P〉0.05 ）, WBC on lth and 6th day （ P〉0.05 ）, accumulated points of chest radiography on lth and 6th day （ P〉0.05 ）, the arterial oxygen gas analysis （ PSaO2 ~〉 0.05, PPaO2 〉 0.05, PPaCO2 ~ 0.05 ）, showed no significant differences. Conclusions： Atomizing with Qingkailing Injection after resection of esophageal carcinoma or cardiac carcinoma could dilute the sputum, and promote spitting phlegm.But there are no significant differences in body temperature, hemogram, chest radiography and the arterial oxygen gas analysis.