聚束蛋白和肝细胞生长因子在鼻内翻性乳头状瘤中的表达及临床意义

Expression and significances of FSCN1 and HGF in nasal inverted papilloma

目的:探讨聚束蛋白(FSCN1)和肝细胞生长因子(HGF)在鼻内翻性乳头状瘤(NIP)中的表达及其在该病恶性转化中的临床意义。方法:应用免疫组织化学方法检测12例慢性肥厚性鼻炎下鼻甲黏膜组织(对照组)、40例NIP(NIP组)及14例NIP恶变(恶变组)中FSCN1和HGF的表达情况。结果:在NIP组和恶变组中FSCN1的阳性表达率分别为52.5%和78.6%,均明显高于对照组(8.3%),差异均有统计学意义(均P<0.05)。恶变组中HGF的表达率为85.7%,显著高于对照组,差异有统计学意义(P<0.05)。NIP组中HGF的阳性表达率为40.0%,高于对照组,但两者之间的差异无统计学意义(P>0.05)。FSCN1/HGF在NIP组和恶变组中的表达呈正相关。结论:FSCN1/HGF的表达异常和NIP的发生及其恶变密切相关,联合检测FSCN1/HGF有助于早期预测NIP的恶变。

Objective：To study the expressions of FSCN1 and HGF in nasal inverted papilloma（NIP）and explore their role in occurrence and development of this disease.Method：Immunohistochemical method was used to determine the expression of FSCN1 and HGF in 12 cases of chronic hypertrophic rhinitis,40 cases of NIP and 14 cases of NIP with malignant transformation.Result：FSCN1 was expressed in 52.5% of NIP,78.6% of NIP with malignant transformation and 8.3% of inferior turbinate of chronic hypertrophic rhinitis.Expression of FSCN1 was significantly higher in NIP and NIP with malignant transformation than in inferior turbinate（P0.05）.HGF was expressed in 85.7% of NIP with malignant transformation and 8.3% of inferior turbinate.Expression of HGF was significantly higher in NIP with malignant transformation than in inferior turbinate（P0.05）.HGF was expressed in 40.0% of NIP,which was higher than that of inferior turbinate.Expression of HGF was positively related to expression of FSCN1 in NIP and NIP with malignant transformation.Conclusion：The abnormal expression of FSCN1 and HGF may be closely correlated with NIP and its malignant process.Analysis of FSCN1 and HGF expression in NIP may be useful in predicting malignant transformation.