早产儿视网膜病变多中心临床试验介绍-LIGHT—ROP、STOP—ROP和BEAT—ROP

Introduction of multicenter clinical trials for retinopathy of retinopathy： LIGHT-ROP, STOP-ROP and BEAT-ROP

循证医学证据对于临床防治早产儿视网膜病变（ROP）具有重要意义。已证实视网膜消融术（冷冻和激光）治疗ROP有效，但对周边视网膜具有一定的破坏性，因而需要寻找更安全的治疗方法。继“冷冻治疗ROP（CRYO．ROP）”和“早期治疗ROP（ET—ROP）”临床试验之后，美国又先后发起了“减少光照对ROP的效应（LIGHT—ROP）”、“阈值前ROP补充氧疗（STOP—ROP）”和“贝伐单抗消除ROP的血管生成威胁（BEAT—ROP）”等多项重要的多中心临床试验，旨在探索新的治疗途径。本文综述了ROP多中心临床试验LIGHT—ROP、STOP-ROP和BEAT—ROP的目的、试验设计、主要结果和结论。（国际眼科纵览，2012，36：21—25）

Evidence-based medicine is very important to clinical prevention and treatment for retinopathy of prematurity（ROP）. Although retianl ablation including cryotherapy and laser has been proved to be effective in treating ROP, it can be destructive to the peripheral retina to some extent. Therefore, better and safer therapies are desired. After the two influential clinical trials--＂ Cryotherapy forretinopathy of prematurity（CRYO-ROP）＂ and ＂Early treatment for retinopathy of prematurity study（ET-ROP）＂, other significant muhicenter clinical trials has been initiated successively in the United States in order to explore novel therapeutic ways, such as ＂The effects of light reduction on retinopathy of prematurity （LIGHT-ROP） ＂, ＂Supplemental therapeutic oxygen for prethreshold retinopathy of prematurity （STOP-ROP）＂ and ＂ Bevaci- zumab eliminates the angiogenic threat of retinopathy of prematurity （BEAT-ROP）＂. In this article, we re- viewed the goals, designs, main results and conclusions of the three trials. （Int Rev Ophthalmol, 2012, 36： 21-25）