摘要
免疫作用在年龄相关性黄斑变性（AMD）的玻璃膜疣形成、视网膜色素上皮萎缩、脉络膜新生血管形成等病变形成过程中贯穿始终。视网膜为免疫赦免器官并维持自身免疫稳态，该稳态失衡时免疫反应过度则演变为慢性炎症，持久的炎症反应可导致眼内炎症细胞积累、补体分子积累、免疫复合物沉积，造成组织损伤。目前认为，免疫产物沉积于眼主要涉及慢性炎症、亚炎症、自我吞噬功能失代偿等机制。本文就近年来在视网膜老化、免疫异常、自我吞噬作用与AMD发生发展相关的研究进展做一综述。（国际眼科纵览，2012，36：46-51）
Immune mechanism plays an important role in pathology of AMD, including formation of drusen, geographic atrophy and ehoroidal neovascularization （CNV）. Retina is an ＂ immune privileged＂ site, which could maintain immune homeostasis in one ＇s life. Disruption of this homeostatic mechanisms seems crucial in allowing excessive activation of immunologic response and the resultant chronic inflamma- tion, which could lead to accumulation of resident immune cells, complement components and deposition of immune complex, all above may result in ocular tissue damage and degeneration. At present, deposition of immunoreactive products in ocular tissues is involved in chronic inflammation, para-inflammation, dysfunction of autophagy and so on. This article reviews recent studies on development of AMD relevant to retina aging, dysfunction of immunity and autophagy. （ [nt Rev Ophthalmol, 20]2, 36： 46-51 ）
出处
《国际眼科纵览》
2012年第1期46-51,共6页
International Review of Ophthalmology
