软骨细胞移植修复髁突软骨损伤的实验研究

The repairment of the condylar cartilage defect by transplantation of chondrocytes embedded in the collagen membrane

目的 研究软骨细胞移植修复髁突软骨损伤后的效果及修复组织的性质。方法 选用成年雄性白兔 5 3只 ,分成 5组。第 1组 :细胞移植组 ;第 2组 :单纯胶原膜植入组 ;第 3组 :在实验动物的髁突前斜面形成直径 2mm的全层损伤后 ,未植入任何物品 ;第 4组 :空白手术对照组 ;第 5组 :正常对照组。结果 细胞移植组动物的髁突软骨损伤区形成软骨组织修复。

Objective To study the effect of repairing the defect on the condylar articular cartilage by chondrocyte transplantation. Methods A full thickness defect was made in the condylar articular cartilage of the adult rabbit. The isolated condylar chondrocytes of the rabbits cultured in vitro for one week were embedded in the collagen membrane, and then transplantated into the defect. Results The defects of the condylar articular cartilage were repaired with cartilage tissue. Conclusions The defect of the condylar articular cartilage could be repaired with articular cartilage like tissue by transplantation of the condylar chondrocytes.