早期糖尿病肾脏疾病与糖尿病勃起功能的相关性研究

Correlation study of early diabetic kidney disease with diabetic male erectile dysfunction

目的探讨早期糖尿病肾脏疾病（DKD）与男性2型糖尿病患者勃起功能障碍（DED）之间的相关性。方法对2007年4月至2010年2月在沈阳军区总医院内分泌科住院的353例男性2型糖尿病患者进行问卷调查，采用勃起功能国际指数（IIEF-5）评分问卷对其勃起功能进行评分，按照有无DKD分为两组，比较两组患者基础信息和勃起功能。结果两组糖尿病患者中年龄、空腹血糖、糖化血红蛋白（HbAlc）、胰岛素抵抗指数（HOMA—IR）、血压、雌激素、睾酮比较差异无统计学意义（P〉0．05），两组糖尿病患者血管和神经并发症方面比较差异亦无统计学意义（P〉0．05），两组糖尿病患者糖尿病病程、体质量指数（BMI）、勃起功能国际指数（IIEF-5）评分方面比较差异有统计学意义（P〈0．05）。糖尿病肾脏疾病组107例，ED患病率为82．2％；非糖尿病肾脏疾病组246例，ED患病率为61．8％；糖尿病肾脏疾病与DED的发病显著正相关（P〈0．01）。结论糖尿病肾脏疾病可能是男性2型糖尿病患者ED患病率增加的一个重要因素。控制糖尿病降低早期糖尿病肾脏疾病发病率对降低DED的发病率有重要意义。

Objective To investigate the correlation of early diabetic kidney disease with type 2 diabetic male erectile dysfunction （ED）. Methods Three hundred and fifty-three diabetic male patients were classified into early diabetic kidney disease group （30 rag/24 h ≤ UAER 〈 300 mg/24 h and renal function abnormal）and nondiabetic kidney disease group （UAER 〈 30 mg/24 h and renal function normal）. All the diabetic male patients accepted physical examination and past history and blood biochemistry detection. Erectile function（EF） was evaluated with international index of EF（IIEF-5）. Results Eighty-eight patients（82.2% ） were found to have ED in early diabetic kidney disease group, and 152 patients（61.8% ） in nondiabetic kidney disease group. Diabetic kidney disease was positively correlated with diabetic erectile dysfunction （P 〈 0. 01 ）. Conclusions Early diabetic kidney disease plays an important role in the development of ED in diabetic male patients. Controlling of diabetes and reduce the incidence of early diabetic kidney disease has important significante for reducing the incidence of DED.