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对数线性模型在病例-父母对照研究中的应用 被引量：2

Application of log-linear model in the case-parent triad study
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摘要 介绍应用对数线性模型分析病例一父母对照研究设计的方法。以亚甲基四氢叶酸还原酶基因（MTHFR）c677T与唇腭裂的关联研究为例，应用对数线性模型分析母亲、子代基因及其交互作用与唇腭裂的关系。结果显示变异型纯合子母亲的子代发生唇腭裂的风险低于野生型纯合子母亲的子代，S2=0．43（95％CI：0．19～0．95），未发现唇腭裂与子代基因及母子交互作用相关。应用对数线性模型分析病例一父母对照研究设计的方法尤其适用于妊娠期疾病与源于胚胎时期疾病等的病因学研究。 We were introducing a log-linear model for case-parent triad study. Data from a previous study of the association between MTHFR C677T and cleft lip with or without cleft palate （CL/P） was analyzed, in order to investigate the maternal effect, fetal effect and their interaction, using a series of log-linear models. Our results showed that mothers who were carrying two copies of MTHFR C677T variant alleles appeared to have reduced the risk of CL/P in offspring, comparing to those with homozygous of wild-type allele. With S2=0.43 （95% CI： 0.19-0.95）. No significant association was found for fetal genotype and maternal-fetal interaction with CL/P. Log-linear model method seemed to be useful in the estimation of maternal effect, fetal effect and maternal-fetal interaction, in the case-parent triad study design. This approach showed specific benefit in studies that related to genetic effects on complex diseases such as pregnancy complications and diseases originated from fetus.
作者 朱明 聂绍发 严薇荣
机构地区 华中科技大学同济医学院公共卫生学院流行病与卫生统计学系
出处 《中华流行病学杂志》 CAS CSCD 北大核心 2012年第4期435-438,共4页 Chinese Journal of Epidemiology
基金 基金项目：国家自然科学基金（30700681/H2610,81172679/H2605）
关键词 病例-父母对照研究 对数线性模型 基因多态性 母子交互作用 Case-parent triad Log-linear model Gene polymorphisms Maternal-fetalinteraction
分类号 R-03 [医药卫生]
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二级参考文献27

  • 1Knapp M,Seuchter SA,Baur MP.The haplotype-relative-risk (HRR) method for analysis of association in nuclear families. Am J Hum Genet,1993,52∶1085-1093.
  • 2Schaid DJ,Sommer SS.Genotype relative risks: methods for design and analysis of candidate-gene association studies. Am J Hum Genet,1993,53∶1114-1126.
  • 3Knapp M,Wassmer G,Baur MP. The relative efficiency of the Hardy-Weinberg equilibrium-likelihood and the conditional on parental genotype-likelihood methods for candidate-gene association studies. Am J Hum Genet,1995,57∶1476-1485.
  • 4Schaid DJ.Likelihoods and TDT for the case-parents design. Genet Epidemiol,1999,16∶250-260.
  • 5Spielman RS,McGinnis RE,Ewens WJ. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).Am J Hum Genet,1993,52∶506-516.
  • 6Schaid DJ,Sommer SS.Comparison of statistics for candidate-gene association studies using cases and parents. Am J Hum Genet,1994,55∶402-409.
  • 7Ewens WJ,Spielman RS.The transmission/disequilibrium test: history,subdivision,and admixture. Am J Hum Genet,1995,57∶455-464.
  • 8Schaid DJ. Transmission disequilibrium,family controls,and great expectations. Am J Hum Genet,1998,63∶935-941.
  • 9Sham PC,Curtis D.An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. Ann Hum Genet,1995,59(Pt 3)∶323-336.
  • 10Spielman RS,Ewens WJ. The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet,1996,59∶983-989.

共引文献5

同被引文献16

  • 1Weinberg CR, Umbach DM. A hybrid design for studying genetic influences on risk of diseases with onset early inlife[J]. Am J Hum Genet,2005,77(4) :627-636. DOI: 10.1086/ 496900.
  • 2Weinberg CR, Wilcox AJ, Lie RT. A log-linear approach to case-parent-triad data:assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting IJ]. Am J Hum Genet, 1998, 62 (4) :969-978. DOI: 10.1086/301802.
  • 3Wilcox AJ, Weinberg CR. Distinguishing the effects of maternal and offspring genes through studies of 'case-parent triads' [J ]. Am J Epidemiol, 1998,150(4) :428-429.
  • 4Vermeulen SH, Shi M, Weinberg CR, et al. A hybrid design: case-parent triads supplemented by control-mother dyads J. Genet Epidemiol, 2009, 33 (2) : 136-144. DOI: 10.1002/ gepi.20365.
  • 5Epstein MP, Veal CD, Trembath RC, et al. Genetic association analysis using data from triads and unrelated subjects [J]. Am J Hum Genet, 2005,76(4) : 592-608. DOI: 10.1086/429225.
  • 6Schaid DJ, Sommer SS. Genotype relative risks: methods for design and analysis of candidate-gene association studies [J ]. Am J Hum Genet, 1993,53(5) : 1114-1126.
  • 7Dempster AP, Laird NM, Rubin DB. Maximum likelihood from incomplete data via the EM algorithm [J]. J Roy Statist Soc, 1977,39( 1 ) : 1-38.
  • 8van Den Oord E J, Vermunt JK. Testing for linkage disequilibrium, maternal effects, and imprinting with (In) complete case-parent triads, by use of the computer program LEM [J]. Am J HumGenet,2000,66( 1 ) :335-338. DOI: 10.1086/302708.
  • 9Nagelkerke NJD, Hoebee B, Teunis P, et al. Combining the transmission disequilibrium test and case-control methodology using generalized logistic regression[J]. Eur J Hum Genet, 2004, 12( 11 ) :964-970. DOI: 10.1038/sj.ejhg.5201255.
  • 10Skare 0, Jugessur A, Lie RT, et al. Application of a novel hybrid studyq design to explore gene-environment interactions in orofacial clefts[ J]. Ann Hum Genet, 2012,76(3 ) : 221-236. DOI: 10.1111/ j. 1469-1809.2012.00707 .x.

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中华流行病学杂志
2012年 第4期

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