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星形胶质细胞上调基因-1在恶性肿瘤中作用的研究进展 被引量：3

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摘要 星形胶质细胞上调基因-1(astrocyte elevated gene-1,AEG-1)最初通过快速差减杂交技术在HIV-1或肿瘤坏死因子-α诱导的原代人胚胎星形胶质细胞中鉴定发现。AEG-1定位于8q22,由3611个碱基组成,编码的蛋白质分子量64 kDa,主要定位于核周和类内质网结构区。AEG-1是Ha-ras和PI3K/AKT/C-Myc途径的下游靶分子。AEG-1通过调节NF-kB途径、PI3K/AKT途径及Wnt/β-catenin等途径发挥作用。目前研究发现AEG-1在乳腺癌、食管癌、肝癌、前列腺癌和肺癌等肿瘤中过表达,并与肿瘤发生、发展、转移及耐药等密切相关,成为肿瘤患者预后的独立危险因素,但其潜在功能和具体调控通路需要进一步研究。本文就AEG-1在恶性肿瘤中作用的研究进展作一综述,旨在为以AEG-1分子为靶点选择合适的肿瘤抑制剂及靶向治疗提供新的视野。
作者 袁相贵 赵小英
机构地区 浙江大学医学院附属第二医院滨江院区 杭州市滨江医院内科 浙江大学医学院附属第二医院血液科
出处 《实用肿瘤杂志》 CAS 2012年第2期200-204,共5页 Journal of Practical Oncology
关键词 肿瘤 神经细胞瘤 癌基因 信号传导 抗药性 肿瘤 综述
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献40

  • 1Su ZZ,Kang DC,Chen Y,et al.Identification and cloningof human astrocyte genes displaying elevated expressionafter infection with HIV-1 or exposure to HIV-1 envelopeglycoprotein by rapid subtraction hybridization,RaSH[J].Oncogene,2002,21(22):3592-3602.
  • 2Khuda II,Koide N,Noman AS,et al.Astrocyte elevatedgene-1(AEG-1)is induced by lipopolysaccharide as toll-like receptor 4(TLR4)ligand and regulates TLR4signalling[J].Immunology,2009,128(1 Suppl):e700-706.
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同被引文献50

  • 1Yoo BK, Emdad L, Lee SG, et al. Astrocyte elevated gene-1 ( AEG-1 ) : A multifunctional regulator of normal and abnormal physiology [ J ]. Pharmacol Ther, 2011 , 130 ( 1 ) : I - 8.
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  • 3Kang DC, Su ZZ, Sarkar D, et al. Cloning and eharacterizat tion of HIV- 1 -inducible astroeyte elevated gene- 1 , AEG- 1 [J]. Gene, 2005, 353(1) : 8-15. [.
  • 4Emdad L, Sarkar D, Su ZZ, et al. Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1 : implica- tions for tumor progression and metastasis [ J ]. Cancer Res, 2006, 66(3): 1509 -1516.
  • 5Brown DM, Ruoslahti E. Metadhefin. A cell surface protein inbreast tumors that mediates lung metastasis [ J ]. Cancer Cell, 2004, 5(4): 365 -374.
  • 6Suthedand HG, Lam YW, Briers S, et al. 3D3/lyric: a no- vel transmembrane protein of the endoplasmie reticulum and nu- clear envelope, which is also present in the nueleolus E J ] Exp Cell Res, 2004, 294(1) : 94-105.
  • 7Kikuno N, Shiina H, Urakami S, et al. Knockdown of astro- cyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity [ J ]. Oncogene, 2007 , 26 (55) : 7647 -7655.
  • 8Lee SG, Jeon HY, Su ZZ, et al. Astrocyte elevated gene-1 contributes to the pathogenesis of neumblastoma [ J ]. Onco- gene, 2009, 28(26): 2476-2484.
  • 9Yoo BK, Emdad L, Su ZZ, et al. Astrocyte elevated gene-1 regulates hepatoeellular carcinoma development and progression [J. J ClinInvest, 2009, 119(3): 465 -477.
  • 10Li J, Yang L, Song L, et al. Astroeyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcrip- tional factor FOXO1 [ J ]. Oneogene, 2009, 28 ( 36 ) : 3188 -3196.

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实用肿瘤杂志
2012年 第2期

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