肿瘤微环境中的非肿瘤细胞

Non-tumor cells in tumor microenvironment

肿瘤微环境是影响肿瘤发展恶化的重要因素,其中的非肿瘤细胞对于肿瘤细胞及微环境的形成和改变具有决定性作用。该文从肿瘤微环境的组成及其功能特点和影响肿瘤微环境关系密切的非肿瘤细胞入手,较全面的阐述了非肿瘤细胞在肿瘤微环境形成过程中的功能作用及影响。

Tumor microenvironment is a spatial structure including many kinds of cells and stroma around them,which interact each other to form a variety of crosstalks.Current research confirms that tumor progress and metastasis are involved in autocrine and paracrine by peritumor cells,which create a robust system that can regulate their response to treatment.Non-tumor cells in tumor environment play a crucial role.Proposed here is the therapy for cancer treatment,which could be more effective in destruction of the tumor microenvironment than just killing the tumor cells.