血尿酸水平与冠心病及其严重程度的关系研究

Relation of Serum Uric Acid Level with Severity of Coronary Artery Disease

目的：研究血尿酸（UA）水平与冠心病（CAD）的发生及其严重程度的关系。方法：根据冠状动脉造影结果将患者251例分为CAD组148例和非CAD组103例，以发生病变的血管支数反映冠心病严重程度，将患者分为A、B、C、D4组，分别对应冠状动脉正常、1支、2支、3支病变，比较各组间尿酸水平。根据尿酸水平按四分位数将患者分为第1～4组。结果：（1）CAD组血尿酸水平高于非CAD组（P〈0．叭），Logistic多因素回归分析显示年龄、天冬氨酸转氨酶、尿酸水平为冠心病的危险因素。（2）尿酸水平与冠脉病变支数呈正相关（rs=0．229，P〈0．01），其中女性组尿酸水平与冠脉病变支数呈正相关（rs=0-317，P〈0．01），而男性组无此相关性（rs=-0．36，P=0．671）。（3）血尿酸水平第3、第4四分位的CAD患病率明显高于第1、第2四分位（P〈0．01）。结论：血清尿酸水平与冠心病的患病率有关，且与冠状动脉病变程度旱正相关。

Objective： To investigate the relationship between the serum uric acid level, incidence of coronary artery disease （CAD） and its severity. Methods： A total of 251 patients who underwent coronary angiography in our hospital were included in this study according to the inclusion criteria. Patients were divided into CAD group （ n=148 ） and Non-CAD group （n=103） according to the results of angiography. The severity of CAD was measured in terms of the number of vessels with lesions. Patients were divided into four groups including A （no vessel with lesion）, B （one-vessel with lesion）, C （two-vessel with lesion） and D （three-vessel with lesion）. The serum uric acid levels were compared between groups. Patients were divid- ed into four subgroups according to the serum uric acid levels. Results： （1）The serum uric acid level was higher in CAD pa- tients than that of Non-CAD patients （P 〈 0.01）. Logistic regression analysis showed that the age, aspartate aminotransferase （AST） and the serum uric acid level were the independent risk factors of CAD. （2）There was a positive correlation between the serum uric acid level and the severity of CAD（rs = 0.229, P 〈 0.01）.The same result was found in female patients （rs = 0.317, P 〈0.01）, but there was no such significant difference in male patients （rs = -0.36, P = 0.671）.（3）A significantly higher percentage of CAD patients was found in serum uric acid levels in the range of quartile 3 and 4 than that of serum uric acid levels of quartile 1 and 2 （P 〈 0.01）. Conclusion： The serum uric acid level was associated with the prevalence rate of CAD, and has a positive correlation with the severity of CAD.