蛋白质摄入量与良性前列腺增生相关性分析

Association between dietary protein intake and benign prostatic hyperplasia

目的检验膳食蛋白质、牛奶及奶类制品与良性前列腺增生(BPH)的关系。方法采用病例对照研究方法,病例为2007-2009年施行BPH手术,年龄在55～90岁的360例男性;对照为与病例年龄相同的360例患其他疾病的男性,对研究对象进行问卷调查,同时用半定量化食物频率调查表(FFQ),调查研究对象膳食情况;采用多元Logistic回归模型检验研究因素与BPH关系的比值比(OR)及其相应的95%可信区间(CI)。结果病例组居住农村者高于对照组,分别为28.3%(102/360)和16.7%(60/360),2组间差异有统计学意义(P<0.05);在调整了年龄及热能的摄入量后,总蛋白质的摄入量与BPH呈负相关(χ2=8.567,P=0.036);与摄入量最低四分位数对照组比较,病例组最高四分位数者的OR值明显降低(OR=0.615,95%CI=0.014～0.930);动物性蛋白质、牛奶及奶类制品的摄入量与BPH呈负相关关系(分别为χ2=10.572,P=0.014和OR=0.731,95%CI=0.545～0.981),但随着每日摄入量的增加,BPH发病的危险性并不呈一致性的降低,与摄入量最低四分位数的对照组比较,病例组最高四分位数者的OR值增加(分别为OR=0.638,95%CI=0.418～0.972和OR=0.636,95%CI=0.292～0.835)。结论膳食蛋白质,尤其是动物性蛋白质可使BPH的危险性降低,而摄入过多动物蛋白却使这种保护性作用降低。

Objective To examine the association between the intakes of dietary protein,milk and dairy products and the risk of benign prostatic hyperplasia（BPH）.Methods A case-control study was conducted among 360 men who were aged 50-90 years and surgically treated for BPH between 2007 and 2009 and 360 gender and age-matched controls who were admitted to the same hospital for diseases other than prostatic conditions.The cases and controls were interviewed during their hospitalization with a standardized structured questionnaire.Data on diet were obtained via a valid semi-quantitative food frequency questionnaire（FFQ）.Odds ratios（OR） and corresponding 95% confidence intervals（CI） of the variables were estimated using unconditional multiple logistic regression model.Results The proportion of the cases living in the rural area was significantly higher than that of in the controls（28.3% vs 16.7%,P〈0.05）.After adjusting for age and energy intake,the total protein intake was inversely related to BPH（χ2=8.567,P=0.036）.Men in the highest quartile of total protein intake were nearly a half less likely to report BPH（OR=0.615,95%CI=0.014-0.930）.The consumptions of animal protein and milk and dairy products were inversely related with BPH（χ2=10.572,P=0.014 and OR=0.731,95%CI：0.545-0.981,respectively）.The relation was attenuated among the subjects with high intake of animal protein（OR=0.638,95%CI：0.418-0.972 and OR=0.636,95%CI：0.292-0.835,respectively）.Conclusion Dietary protein,especially animal protein,was inversely related to BPH.But the relation was attenuated by high intake of animal protein.