卡前列素氨丁三醇防治剖宫产术中、术后出血的临床研究

Clinical application of carboprost tromethamine on prevention and treatment of postpartum hemorrhage in cesarean section

目的:探讨卡前列素氨丁三醇防治剖宫产术中、术后出血的临床疗效。方法:选择有出血高危因素行剖宫产术的产妇120例,分成研究组及对照组,每组60例。两组均在胎儿娩出后常规静脉滴注催产素的基础上,研究组于宫体注射卡前列素氨丁三醇250μg,对照组予卡孕栓1.0mg舌下含服,比较两组术中出血量、产后2h及产后2～24h内的出血量及两组产后出血率。比较两组患者用药前及用药后生命体征变化。结果:研究组术中出血量、产后2h出血量、产后2～24h出血量均少于对照组,差异均有统计学意义(P<0.05),研究组产后出血率低于对照组,差异有统计学意义(P<0.05);两组用药前、后生命体征变化相近,差异无统计学意义(P>0.05)。结论:卡前列素氨丁三醇可有效防治有出血高危因素产妇剖宫产术中、术后出血,快速方便,效果确切,不良反应少。

differences between two groups on intraoperative blood loss, postpartum hemorrhage in 2 h and 2 -24 h （P〈0.05）; And the incidence rate of postpartum hemorrhage in study group was less than that in control group （P 〈 0.05）. There were no significant differences on the change of vital signs before and after treatment （P〈0.05） CONCLUSION： It was effective, rapid and con- venient to use carboprost tromethamine for the prevention and treatment in high hemorrhagic risk fators of PPH during CS with less adverse reaction