基于介电电泳的微尺度颗粒分离研究进展

Research Progress on the Microscale Particle Separation by Dielectrophoresis

对基于连续型、时变型及与其他力场联用的三类介电电泳颗粒分离技术进行了综述。分析表明,连续型介电电泳的分离效果较好,但形式较为单一,一般为二元或顺序分离;时变型介电电泳则可以结合不同特点的分离形式,提高分离的选择性与灵活性;为了兼顾分离的通量、灵活性与分辨率等要求,与其他形式力场联用则是解决问题的有效途径之一。在此基础上,给出了介电电泳技术在分离问题中的几个研究方向,包括拓展至具有复杂结构的颗粒类型,与具体的生物和医学问题相结合向应用领域发展,以及与磁场等外加力场相结合等。

The separation technologies by different dielectrophoresis（DEP） manners,including the continuous DEP,time-varying DEP and the combination of DEP with other forces,are reviewed.The analysis shows that among these methods the continuous DEP is more effective but the separation form is relative simple,which generally can be classified into binary or sequence separation.The time-varying DEP has the ability to integrate different separation forms into one system to improve the selectivity and flexibility.In order to take into account the throughput,flexibility,resolution and other requirements in a separation system,the combination with other force fields is a feasible manner.Based on the discussion above,several research directions of the DEP-based separation technology are proposed,such as the separation of particles with the complex structure,the combination with specific biology and medicine issues toward the application field,and the combination with the magnetic field or other applied force fields.