长春瑞滨致静脉炎的预防和治疗研究述评

Study Comment on the Prevention and Treatment of Phlebitis Caused by Vinorelbine

目的:探讨长春瑞滨导致化疗性静脉炎的机制及防治措施。方法:对近5 a来相关性文献进行分析及归纳。结果:发生机制主要是其较强的刺激性、腐蚀性和细胞毒性所致血管内皮损伤。采用局部物理疗法、中药外敷、西药外敷等治疗手段,可以预防和治疗静脉炎。结论:目前没有一种医疗界公认的、有效的药物防治化疗性静脉炎。因此,在临床工作中寻求更加安全、有效、快速的防治措施,将成为未来防护化疗性静脉炎的发展方向。

Objective：To discuss the genesis mechanism of chemotherapeutic phlebitis caused by Vinorelbine and its prevention and treatment measures.Methods：Relative literature in recent five years were analyzed and concluded.Results：Genesis mechanism was mainly vascular endothelium injury caused by quite strong irritant,causticity and cytotoxicity of Vinorelbine.By adopting treatment methods of local physical therapy,external application of Chinese medicine and western medicine,phlebitis could be prevented and treated.Conclusion：There is no effective medicine recognized by medicine treatment field that can prevent and treat chemotherapeutic phlebitis at present.Therefore,to explore safer,faster and more effective prevention and treatment measures in clinical work will become the development direction of preventing and protecting chemotherapy phlebitis in the future.