ω-3多不饱和脂肪酸对术后危重患者炎症曼应和营养状态的影响

Effects of ω-3 Polyunsaturated Fatty Acid on Inflammatory Response and Nutritional State of Patients after Operation

目的：研究ω-3多不饱和脂肪酸对术后危重病人炎症反应和营养状态的影响。方法：选择术后需完全肠外营养支持的危重病患者40例．随机分为试验组和对照组．每组20例。两组患者术后连续行7d肠外营养支持治疗，试验组每天加用ω-3多不饱和脂肪酸10g。比较两组治疗前、治疗后2d和Bd的炎症反应指标（白细胞、中性粒细胞和C反应蛋白水平）和营养状态指标（总蛋白，前白蛋白、转铁蛋白和淋巴细胞水平）以及手术前后体重变化（体重差）。结果：两组患者的基线一致，具有可比性（P〉0．05）。术后2d两组患者炎症反应指标和营养状态指标水平比较．差异无统计学意义（P〉0．05）；术后8d试验组中性粒细胞和C反应蛋白水平均明显低于对照组．淋巴细胞水平明显高于对照组．差异有统计学意义（P〈0．05）。两组患者的体重差比较差异无统计学意义（P〉0．05）。结论：ω-3多不饱和脂肪酸能够有效减轻术后危重病患者的炎症反应．改善患者的术后营养状态。

Objective： To investigate the effects of ω-3 polyunsaturated fatty acid（PUFA） on inflammatory response and nutritional condition for patients affer operation. Methods： Forty postoperative patients were divided randomly into an experimental group （20 cases） and a control group （20 cases）. Parenteral nutrition was conducted in continuous 7 days after operation. Comparing with the control group, a dose of 10g of ω-3 PUFA was given to the experimental group once a day for 7 days after operation in addition. Relative indexes about inflammatory response （WBC, neutrophilic granulocyte and C-reaction protein） and nutrition （total protein, albumin, prealbumin, sidrophilin and lymphocyte） were measured before operation, the 2nd and the 8th day after operation respectively. Reduction of body mass was also recorded. Results： The baseline between experimental group and control group was comparable （P〉0.05）.The levels of indexes about inflammatory response （WBC, neutrophilic grahulocyte and C-reaction protein） and nutrition （total protein, albumin, prealbumin, sidrophilin and lymphocyte.） between experimental group and control group did not reach statistically significant difference in the 2nd day after operation （P〉0.05）. The levels of neutrophilic granulocyte and C-reaction protein in experimental group were lower than that of the control group, and the level of lymphocyte in experimental group was higher than that of the control group in the 8th day after opration, and aU of them reach statistical significant difference （P〈0.05）. there was no statistical difference in reduction of body mass between experimental group and control group （P〉0.05）. Conclusion： ω-3 PUFA can depress the excessively inflammatory reaction and improve the nutrition condition of patients after opration.