我国六个区域2006年1～59岁人群乙型肝炎病毒感染现状及疫苗接种情况分析

The Seroepidemiological Study and Vaccination Status Analysis on Viral Hepatitis B among Population Aged 1-59 Years in Six Areas of China in 2006

目的了解我国华北、东北、华东、中南、西南和西北地区,2006年1～59岁人群乙型肝炎(乙肝)病毒(Hepatitis B Virus,HBV)感染现状及乙肝疫苗(Hepatitis B Vaccine,HepB)接种情况。方法系统分析2006年全国乙肝血清流行病学调查资料。结果华北、东北、华东、中南、西南和西北地区,2006年1～59岁人群HepB接种率分别为50.81%、53.78%、50.02%、47.93%、31.21%和47.60%;乙肝病毒表面抗原(HBV Surface Antigen,HBsAg)流行率分别3.83%、5.56%、7.76%、9.12%、7.92%、4.87%;抗乙肝病毒表面抗原抗体(Antibody to HBsAg,Anti-HBs)流行率分别42.79%、46.44%、48.76%、57.36%、49.74%、46.42%。结论我国六个区域2006年1～59岁人群HBsAg流行率均有不同程度下降,Anti-HBs流行率有所上升,我国自1992年HepB纳入儿童计划免疫管理效果显著。

Objective To understand the status of the hepatitis B virus（HBV）infection and the hepatitis B vaccine （HepB） coverage in the North, Northeast, Eastern, Southwestern, Centralsouth and Northwest of China in 2006. Methods We analyzed the seroepidemiological survey data in China in 2006. Results Among the 1-59 years-old population, the coverage of HepB vaccination was 50.81%, 53.78%, 50.02%, 47.93%, 31.21% and 47.60% respectively, and the prevalence of hepatitis B virus surface antigen （HBsAg）was 3.73%, 5.37%, 7,72%, 8.84%, 8.05% and 4.73% respectively, and the prevalence of antibody to HBsAg （anti-HBs）was 41,98%, 45.69%, 48.58%, 57.49%,50.84%, and 46.57% respectively in the North, Northeast, Eastern, Southwestern, Centralsouth and Northwest of China. Conclusion The prevalence of HBsAg of the six administrative areas in China decreased and the prevalence of anti-HBs increased obviously at different level. The effect of vaccination is very successful since the HepB integrated into EPI in 1992.