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阿司匹林对降低胃癌发病率的作用 被引量:6

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摘要 目的探讨阿司匹林对降低胃癌发病率的作用。方法设服用过阿司匹林的患者为观察组,未服用过阿司匹林的患者为对照组,统计分析两组患者的胃癌发生率的情况。结果两组患者的胃癌发生率比较显示,10年内使用过阿司匹林的患者胃癌的年发病率为十万分之7.5;10年内未使用过阿司匹林的患者组发生胃癌的年发病率为十万分之11.5,观察组的发病率与对照组的发病率间存在着差异统计学意义(P<0.05)。结论目前临床上对于阿司匹林的探索,将会在胃癌等肿瘤及其癌前病变的化学预防领域中取得巨大的贡献。
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出处 《中国现代药物应用》 2012年第5期86-87,共2页 Chinese Journal of Modern Drug Application
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  • 1Husain SS, Szabo IL, Tamawski AS. NSAID inhibition of GI cancer growth: clinical implications and molecular mechanisms of action [ J ]. Am J Gastroenterol, 2002, 97(3) : 542 -553.
  • 2Kim KY, Seol JY, Jeon GA, et al. The combined treatment of aspirin and radiation induces apoptosis by the regulation of bcl-2 and caspase-3 in human cervical cancer cell[J]. Cancer Lett, 2003,189(2) : 157 - 166.
  • 3Escarcega RO, Fuentes-Alexandro S, Garcta-Carrasco M, et al. The transcription factor nuclear factor-kappa B and cancer[J]. Clin Oncol, 2007, 19(2) : 154 - 161.
  • 4Hayden MS, Ghosh S. Shared principles in NF-KB signaling[J].Cell, 2008, 132(3): 344-362.
  • 5Chan AT, Giovannucci EL, Meyerhardt JA, et al. Longterm use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer [ J]. JAMA, 2005, 294(8) : 914 -923.
  • 6Ali S, Mann DA. Signal transduction via the NF-KB pathway: a targeted treatment modality for infection, inflammation and repair[ J ]. Cell Boichem Funct, 2004, 22(2) : 67 -79.
  • 7Redlak MJ,Power JJ, Miller TA. Apoptosis by aspirin: roles of NF-KB and PKC signaling [J]. J Surg Res, 2008, 145 ( 1 ) : 66 - 73.
  • 8[1]Fournier DB, Gordon GB. Cox-2 and colon cancer: potential targets for chemoprevention[J]. J Cell Biochem, 2000, 34(Suppl): 97-102.
  • 9[2]Bellosillo M, Pique M, Barragan M, et al. Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells[J]. Blood, 1998, 92(4): 1406-1414.
  • 10[3]Kojima M, Morisaki T, Uchiyama A,et al. Association of enhanced cyclooxygenase-2 expression with possible local immunosuppression in human colorectal carcinomas[J]. Ann Surg Oncol, 2001, 8(5): 458-465.

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  • 1韩际奥,陈其奎,黄志清,黄开红,陈锦武,朱兆华.阿司匹林对胰腺癌细胞周期的影响及其机制[J].中国病理生理杂志,2006,22(2):368-371. 被引量:8
  • 2Weiser MA, Cabanillas M, Vu K, et al. Diagnostic evaluation of patients with a high suspicion of malignancy: comorbidities and clinical predictors of cancer [ J ]. Am J Med Sci, 2005, 330 (1): 11-18.
  • 3马爽,童英,李春东,等.妇科恶性肿瘤患者血小板数量变化及意义[J].中华临床医师杂志,2012,6(18):5698-5700.
  • 4Gungor T, Kanat-PektasM, SucakA, et al. The role of thrombo- cytosis in prognostic evaluation of epithelial ovarian tumors [ J ]. Arch Gyoecol Obstet, 2009, 279 (1) : 53 -56.
  • 5Yu D, Liu B, Zhang L, et al. Platelet count predicts prognosis in operable non-small cell lung cancer [ J ]. Experim Therap Med, 2013, 5 (5): 1351-1354.
  • 6Wan S, Lai Y, Myers RE, et al. Preoperative platelet count as- sociates with survival and distant metastasis in surgically resected colorectal cancer patients? [ J]. J Gastrointest Cancer, 2013, 44 (3) : 293 - 304.
  • 7Shimada Y, Kato T, Ogami K, et al. Production of thrombopoie- tin (TPO) by rat hepatocytes and hepatoma cell lines [ J]. Exp Hematol, 1995, 23:1388 - 1396.
  • 8Furuhashi M, Miyabe Y, Oda H. A case of thrombopoietin-pm- ducing ovarian carcinoma confirmed by immunohistochemistry [J]. Gynecol Oncol, 1999, 74: 278-281.
  • 9Ciurea SO, Hoffman R. Cytokines for the treatment of thrombocy- tooenia [J]. Semin Hematol. 2007. 44: 166-182.
  • 10Tas F, Oguz H, Argon A, et al. Thevalue of serum levels of IL-6, TNF-alpha, and erythropoietin in metastatic malignant melanoma : serum IL-6 level is a valuable prognostic factor at least as serum LDH in advanced melanoma [ J ]. Med Oncol, 2005, 22:241-246.

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