乳腺癌组织SULT1E1蛋白表达与临床病理学特征及预后相关性的研究

Association research of expression of SULT1E1 with characteristic of clinical pathology and prognosis in breast cancer

目的:探讨乳腺癌组织SULT1E1的表达,并分析其与临床病理学特征及预后因素的相关性。方法:采用免疫组织化学二步法检测129例乳腺癌组织和癌旁正常组织SULT1E1的表达情况,应用Kaplan-Meier法行单因素生存分析SULT1E1的表达与临床病理学特征及预后的关系。结果:乳腺癌组织中SULT1E1的阳性表达率(25.6%)明显低于癌旁组织(45.0%),差异有统计学意义,P<0.05;SULT1E1的表达与乳腺癌患者年龄、肿瘤大小、淋巴结转移和病理类型以及是否有远处转移等无明显相关性,P>0.05。Kaplan-Meier生存分析曲线显示,SULT1E1阳性表达患者的术后无复发生存率较阴性表达患者明显增高,χ2=4.943,P<0.05。结论:乳腺癌组织SULT1E1低表达者提示预后不佳,SULT1E1检测有可能成为判断乳腺癌分期和预后的重要分子标志,并成为重要的预后因素。

OBJECTIVE： To clarify the expression of SULT1E1 in breast cancer and its relationship with clinicopathologic characteristics and prognosis of patients of breast cancer.METHODS： Expression of SULT1E1 protein was detected by the method of immunohistochemistry in 129 cases on cancerous and adjacent non-cancerous paraffin-embedded,then the prognosis of breast cancer was evaluated by Kaplan-Meier survival analysis,and the relationship between expression of SULT1E1 protein and clinicopathological indices was analyzed by statistics.RESULTS： The positive rate of SULT1E1 protein in breast cancer（25.6%） was significantly lower than that in normal breast tissues（45.0%）.The positive rate of SULT1E1 protein in breast cancer was not related to age,tumor size,lymph node metastasis,pathological types or distant metastasis（P〉0.05）,Kaplan-Meier survival analysis showed that the survival rate of positive SULT1E1 protein expression patients was significantly higher than that of negative SULT1E1 protein expression patients（χ2=4.943,P〈0.05）.CONCLUSIONS： SULT1E1 protein is lower expressed in breast cancer,and it may relate to bad prognosis.It should be the important molecular marker to predict the clinicopathologic stage and prognosis of breast cancer.