摘要
目的:总结国内外研究miR-145与肿瘤关系的文献,评价miR-145在肿瘤发生、发展中的作用。方法:以"miR-NAs、miR-145、肿瘤"为关键词,检索1993-2011年PubMed及CNKI期刊全文数据库。纳入标准:1)miR-145基因结构及生物学特性的研究;2)miR-145与肿瘤发生发展关系的研究;3)miR-145与肿瘤诊断、治疗和预后关系的研究。根据纳入标准,纳入分析30篇文献。结果:miR-145定位于5号染色体肿瘤相关的脆性位点上,在多种组织的恶性肿瘤中miR-145表达明显下调。过表达miR-145可抑制肿瘤细胞增殖及诱导肿瘤细胞凋亡。检测血清中miR-145的含量,有助于肿瘤的早期诊断。肿瘤组织中miR-145的表达量与患者放化疗疗效及预后密切相关。结论:miR-145是一个潜在的肿瘤生物标志,有可能成为肿瘤治疗的新靶标。
OBJECTIVE： To review the relationship between miR-145 and tumor,and evaluate the significance of miR-145 in initiation and progress of tumor.METHODS： ＂microRNAs,miR-145,tumor＂ were searched as Key words by PubMed and CNKI series full-text database retrieval system from 1993 to 2011.Inclusion criteria： 1） research of structure and bionomics of miR-145;2） the relationship between miR-145 and tumor,especially in cell proliferation;3） miR-145 and tumor diagnosis,therapy and judgment of prognosis.By extracting according to the choice criteria,30 papers were analyzed.RESULTS： miR-145 is located on chromosome 5 with tumor-associated fragile sites.MiR-145 is under-expressed in tumor tissues and capable of inhibiting tumor cells growth and inducing apoptosis.Expression of miR-145 in serum from patient with tumors may be detected,which can contribute to early diagnosis of cancer.MiR-145 expression in tumor tissues is also closely related with effectiveness of radio-chemo therapy and prognosis.CONCLUSION： miR-145 is a potential cancer biomarker and possibly serves as a novel target for cancer therapy.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2012年第4期317-320,共4页
Chinese Journal of Cancer Prevention and Treatment
基金
上海市科学技术委员会基金(10JC1409200)
