石家庄市赞皇县健康儿童肠道病毒携带情况分析

Analysis of enterovirus-carrying situation in healthy children in Zanhuang county of Shijiazhuang.

目的:了解石家庄市赞皇县健康儿童在手足口病(HFMD)不同流行时期肠道病毒的携带情况,为当地手足口病发病强度和病原学特征预测提供科学依据。方法:选择赞皇县11个乡共161名5岁以下健康儿童采集其粪便标本用逆转录聚合酶链反应(RT-PCR)方法进行肠道病毒核酸检测,对其中发病严重的张楞乡59名健康儿童进行了3次跟踪调查和病原检测。结果:161份健康儿童便标本中,肠道病毒(EV71、CoxA16、其他肠道病毒)阳性44份,肠道病毒携带率为27.33%;其中EV71和其他肠道病毒阳性各22份,其携带率均为13.66%。不同乡携带率有差异,手足口病流行不同时期携带率和优势毒株均不同。结论:赞皇县健康儿童肠道病毒携带率与其手足口病发病强度变化趋势一致,开展健康儿童肠道病毒携带情况调查可作为当地手足口病发病强度预测的参考。

Objective：To understand the enterovirus-carrying situation in healthy children in Zanhuang county of Shijiazhuang in different epidemic periods of HFMD.And to provide scientific basis for predicting popular strength and etiological characteristics of HFMD.Methods：The stool specimens were collected from 161 healthy children under 5 years old in 11 townships of Zanhuang county.Three follow-up were carried out for 59 healthy children in Zhangleng township.The stool specimens were detected by RT-PCR method.Results：The carry rate of 11 township＇ children were different.There exist change about advantage strain in different period of HFMD.The 44 of 161 stool samples of healthy children were positive.The rate was 27.33%;Among the 44 cases,22 were EV71-positive and 22 were other intestinal virus-positive.The rate of EV71 and other intestinal virus were 13.66%,respectively.The enterovirus-carrying rate was consistent with HFMD morbidity.Conclusion： The enterovirus-carrying rate and disease intensity of HFMD show the same trend,the investigation of enterovirus-carrying can predict the situation of HFMD.