心安灵对麻醉犬血流动力学的影响

Xinanling's Effects on Haemodynamics of Anesthetized Dogs

目的探讨心安灵对麻醉犬血流动力学的影响。方法观察心安灵对麻醉犬开胸后的血压、心率、心输出量、冠脉血流量、耗氧量等指标的影响。结果心安灵可显著降低麻醉犬的舒张压、脉压差、心率、血管总外周阻力和总耗氧量,同时能增加麻醉犬心输出量、每搏输出量、心脏指数、心搏指数、冠脉流量。结论心安灵在不减少心脏供血功能的基础上,能降低后负荷、减少心脏作功、增强心脏功能,提示心安灵有改善心血管系统的作用。

OBJECTIVE To explore the haemodynamics effect of Xin＇anling on anesthetized dogs.METHODS We observed Xin＇anling＇s influence on blood pressure,heartbeat,cardiac output,coronary blood flow,oxygen consumption,etc.of anesthetized dogs after being taken mid-sternal thoracotomy.RESULTS Xin＇anling significantly reduced diastolic blood pressure,pulse pressure difference,heartbeat,total peripheral vascular resistance,and total oxygen consumption of the dogs.CONCLUSION Xin＇anling can bring down afterload,reduce cardiac work,and improve cardiac function without decreasing blood supply by heart,which indicates that this medicine is able to better cardiovascular system.