血清高敏C反应蛋白、尿酸与老年急性心肌梗死的相关性研究

Correlation of high sensitive C-reactive protein and uric acid in elder acute myocardial infarction

目的探讨老年急性心肌梗死患者血清高敏C反应蛋白(hs-CRP)、尿酸(UA)水平及其与病情的相关性研究。方法选择80例老年急性心肌梗死患者为Ⅰ组,选择70例老年不稳定型心绞痛患者为Ⅱ组,选择60例老年稳定型心绞痛患者为Ⅲ组。比较3组患者血清hs-CRP及UA水平,并对hs-CRP与UA的相关性进行分析。结果Ⅰ组、Ⅱ组及Ⅲ组患者hs-CRP与UA依次降低,差别具有统计学意义(P<0.01);80例Ⅰ组患者中共有39例(48.8%)预后不良(死亡、心律失常及心力衰竭),预后不良患者hs-CRP与UA水平显著高于对照组,差别具有统计学意义(P<0.01);Ⅰ组与Ⅱ组患者血清hs-CRP与UA呈显著相关(P<0.05),而二者在Ⅲ组患者未见相关性(P>0.05)。结论高UA及hs-CRP是老年急性心肌梗死的独立危险因素,二者的联合检测对于预测老年急性心肌梗死的发生及预后具有重要价值。

Objective To explore the correlation of high sensitive c-reactive protein（hs-CRP） and uric acid（UA） in elder acute myocardial infarction.Methods Selected 80 patients with elder acute myocardial infarction as groupⅠ,70 cases with unstable angina as group Ⅱ and 60 subjects of stable angina as group Ⅲ.Serum hs-CRP and UA were compared among three groups and correlation of hs-CRP and UA were analyzed.Results Serum hs-CRP and UA of groupⅠwas higher than that of groupⅡ than that of group Ⅲ（P0.01）;The hs-CRP and UA level of 39 cases of poor prognosis in groupⅠwas much higher than that of the patients of good prognosis（P0.01）.Hs-CRP was significantly correlated with UA in groupⅠand groupⅡ（P0.05）,there was no significant correlation in group Ⅲ（P0.05）.Conclusions High UA and hs-CRP are independent risk factors for elder acute myocardial infarction.Combined detection has important value for the occurrence and prognosis of elder acute myocardial infarction.