养血安胎冲剂防治习惯性流产及对短寿命抑制性T细胞的影响

Effect of Yangxue Antai Granule in Preventing and Treating Habitual Abortion and Its Effect on Short Life TSuppressor Cell LI Entang

探讨抑制性Ｔ细胞（Ｔｓ）的活性对习惯性流产（ＨＡ）的影响，并观察养血安胎冲剂对抑制性Ｔ细胞的调节作用及保胎疗效。方法：应用短寿命抑制性 Ｔ细胞活性检查方法（ＭＴＴ），对５６例ＨＡ孕妇孕早期（治疗前）检查抑制性Ｔ细胞活性，并给予养血安胎冲剂防治。其中对２０例追踪观察了孕中期、孕晚期的抑制性Ｔ细胞活性。同时设立正常孕妇孕早期、正常孕产史未孕及有ＨＡ史未孕妇女作为对照组。结果：防治组抑制性Ｔ细胞活性孕早期比孕中期、晚期均低（Ｐ＜０．０１，Ｐ＜０．００１）；比各对照组也低（分别为Ｐ＜０．０１，Ｐ＜０．００１）。保胎成功率为９８．２％，获子率９８．０％。结论：抑制性Ｔ细胞活性低下可能为ＨＡ的免疫学原因，本冲剂所以保胎成功，可能是对抑制性Ｔ细胞活性起到调节作用所致。

To study the influence of T-suppressor cell (Ts cell) on habitual abortion (HA) and to observe the regulatory effect of Yangxue Antai Granule (YXATG) on Ts cell and its effect on fetus preservation. Methods: Ts cell activity of 56 pregnant women with HA history was tested with method of shot life Ts cell activity (MTT method) during early pregnancy, and were followed up in middle and late pregnancy in 20 cases of them. All the 56 patients received YXATG treatment. Groups of normal early pregnant, normal non-pregnant and non-pregnant women but with history of habitual abortion were involved in this study as control. Results: Ts cell activity in early pregnancy was lower than that of middle and late pregnancy (P<0.01, P<0.001), and also lower than that of the control groups (P<0.01, P<0.001). The successful rate of fetus preservation of YXATG was 98.2%, and 98.0% of the cases got a normal delivery. Conclusion: Low Ts cell activity might be the immunologic etiology of HA. The fetus preservative effect of YXATG might be due to its regulatory effect on Ts cell.