早幼粒细胞白血病基因的功能研究进展

Progress in researches on the function of PML gene

为了解早幼粒白血病基因和维甲酸受体 α(promyelocytic leukemia- retinoic acid receptorα,PML- RARα)的致病机理 ,对野生型 PML 基因的生物学功能的研究进展进行综述。从近年来国内外公开发表的有关报道 ,结合本研究所的部分研究结果 ,提示 PML 的高表达有抑制细胞生长和诱导凋亡的作用 ;PML可能参与基因表达的调控 ;且 PML功能的发挥与其 3个重要功能区和核内定位有关 ;PML与 APL发病有关。表明 PML具有多重生物学活性。

This paper was aimed to review and expound the progress in studies on biological function of wild type PML gene and hence to have a gain in knowledge about the carcinogenesis of PML RARα protein. Related reports issued at home and abroad and some research results from this institute were collected and reviewed. According to the data collected PML gene has many biological activites. High expression of PML gene can inhibit the growth of cells and induce apoptosis; PML gene is possibly involved in the regulation of gene expression. Moreover, the function of PML gene is related to its three important domains and its nuclear location; PML gene is associated with carcinogenesis of APL.