转移性肾癌不同组织学类型对生物化疗的效应

Biochemotherapeutic effects on different histologic types of metastatic renal cell carcinoma

目的 观察转移性肾癌不同组织学亚型间生物化疗的效应差异 ,探讨预测疗效的因素。 方法 对 2 6例转移性肾癌病人应用α 2b干扰素 (第 1周 5× 10 6IU/m2 皮下注射 3次 ,第 2周起增至 10× 10 6IU/m2 ,每周 3次 )与长春花碱 (0 .1mg/kg ,每 3周 1次静脉注射 )联合治疗 6个月。 结果 随访 4～ 48个月 ,完全缓解 1例 ,部分缓解 7例 ,病灶无变化 3例 ,病灶进展 15例。缓解病例均为透明细胞癌 ,病灶进展者则为其他类型癌。 结论 转移性肾癌干扰素与长春花碱联合生物化疗疗效与组织学类型有关 ,透明细胞癌缓解率高。

Objective To assess the biochemotherapeutic effects on different pathologic subtypes of metastatic renal cell carcinoma. Methods A total of 26 patients with metastatic renal cell carcinoma were enrolled to biochemotherapy.Interferon α 2b was injected subcutaneously at a dose of 5×10 6IU/m 2 3 times during the first week and subsequently 10×10 6IU/m 2 3 times a week.Vinblastine was given intravenously at 0.1mg/kg once every 3 weeks.Treatment was continued for 6 months. Results After follow up of 4～48 months there were 1 CR,7 PR,3 NC and 15 PD.CR and PR occurred in patients with clear cell carcinoma and PD in those with other histologic types of renal cell carcinoma. Conclusions Interferon α 2b and vinblastine combination therapy showed high responses in patients with clear cell carcinoma whereas the response has been poor in other histologic types of metastatic renal cell carcinoma.