肺泡蛋白沉积症的影像学诊断及临床应用

The imaging diagnosis of pulmonary alveolar proteinosis

目的探讨肺泡蛋白沉积症(pulmonary alveolar proteinosis,PAP)的影像学表现。方法回顾性分析经支气管肺泡灌洗(broncho-alveolar lavage,BAL)或开胸病理证实8例PAP患者的临床、病理及影像学资料。结果 PAP X线表现为两肺对称或不对称分布磨玻璃样影和实变影,自肺门向外放射,可呈"蝶翼征"。胸部CT变化多样:铺路石征;地图样分布;磨玻璃影;气腔实变影,支气管充气征。结论 PAP具有典型影像学表现,结合临床病史综合分析可作出诊断。

Objective To probe the imaging findings of pulmonary alveolar proteinosis（PAP）.Methods The clinical,pathological and imaging materials of 8 cases＇PAP which were proved by broncho-alveolar lavage（BAL） or open-lung biopsy were retrospectively analyzed.Results Symmetry or dissymmetry ground-glass opacities and consolidation opacities were found in X-ray films,distributed on two lungs,radiated from hila to sides,forming butterfly signs.On CT,a variety of abnormalities were found as follows： crazy paving;distributing geographically;ground-glass and consolidation opacities,air-bronchogram sign.Conclusion PAP showed typical imaging appearance.Taking the clinical history into consideration together,a reliable diagnosis can be made.