血清钾、肌酶及甲状腺激素水平变化对甲亢并周期性麻痹患者预后的影响

Study on effect of serum potassium,muscle enzymes and thyroid hormone levels in patients with hyperthyroidism and periodic paralysis

目的:探讨血清钾、肌酶及甲状腺激素水平变化对甲亢并周期性麻痹(简称甲亢周麻,TPP)患者病情和预后的影响。方法:采用回顾性分析方法选取我院TPP患者50例,用全自动生化分析仪检测血清钾、肌酶及甲状腺激素水平浓度。结果:所有TPP患者与正常参考值比较均有血清钾下降,游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、总三碘甲状腺原氨酸(T3)、总甲状腺素(T4)水平上升,促甲状腺素(TSH)水平下降;其中39例患者肌酸激酶(CK)水平上升;28例患者肌酸激酶同工酶(CK-MB)水平上升;31例患者天门冬氨酸转氨酶(AST)水平上升。血清钾分别与CK、CK-MB、AST各指标之间呈负相关。结论:低钾性周期性麻痹(HOPP)为其临床特点,及时控制甲亢并维持血钾正常是治疗关键,早期诊断及时补钾治疗与预后密切相关,合并甲亢者治疗甲亢同时补钾并加强护理,有助于病情判断,提高治疗效果。

Objective： To study the effect of serum potassium,muscle enzymes and thyroid hormone levels in patients with hyperthyroidism and periodic paralysis.Methods： Retrospective analysis was used to analyze 50 TPP patients in the hospital. Serum potassium,muscle enzymes and thyroid hormone levels were detected with automatic biochemical analyzer.Results： Comparing with reference values,all TPP patients′ serum potassium and TSH decreased,FT3,FT4,T3 and T4 increased.And 39 patients had CK increase.28 patients had CK-MB increase.31 patients had AST increase.Serum potassium was negatively correlated to CK,CK-MB and AST respectively.Conclusion： HOPP was one of the clinical features of HPP.Timely control of hyperthyroidism and maintenance of normal serum potassium was the key to treatment. Early diagnosis and timely potassium supplement were closely related to the prognosis,which contributed to judge disease and improve curative effect.