胸腔置管引流灌注高聚生治疗恶性胸水40例临床观察

Clinical Observation on Malignant Pleural Effusion Treated by Intrapleural Catheterization and Infusion of Highly Agglutinative Staphylococcin (A Report of 40 Cases)

目的 :观察高聚生联合化疗药物胸腔内灌注对恶性胸水的疗效。方法 :采用胸腔穿刺、置入长套管针灌注高聚生及顺铂与单用顺铂疗效对照。结果 :高聚生 +顺铂组 40例 ,有效率 82 5 % ;化疗组顺铂 36例 ,有效率47 2 % (P <0 0 5 )。结论 :经长套管针置入灌注生物制剂 +化疗药物 ,疗效明显优于胸腔内单纯灌注化疗药物 ,因此生物制剂高聚生经长套管针置入胸腔内灌注不失为治疗恶性胸水的有效方法之一。

Purpose: To evaluate the therapeutic effects of infusing highly agglutinative staphylococcin (HAS) and combined-chemotherapeutic drugs into pleural cavity for treatment of malignant pleural effusion Methods: At first the peural effusion was drained out from a intrapleural catheter and then infused the highly agglutinative staohylococcin plus cisplatin, and the control group was infused cisplatin alone, and their therapeutic effects were compared in a randomized trial Results: The response rate of 40 cases of HAS group was 82 8%, whereas the response rate of the 36 cases of control group was 47 2%( P< 0 05) Conclusion: The results showed that the effect of HAS is superior to that of the cisplatin alone and it may be one of the effective ways to control malignant pleural effusion