摘要
目的监测细菌耐药性,依据细菌耐药状况、特点及发展趋势,指导临床用药。方法监测2010年度泉州地区4所重点医院临床分离细菌耐药状况,以WHONET 5.5软件进行数据分析。结果共分离得到致病菌4 160株,其中革兰阳性菌1 535株,占36.9%;革兰阴性菌2 625株,占63.1%。最常见的细菌依次为大肠埃希菌、肺炎克雷伯菌、金黄色葡萄球菌、鲍曼不动杆菌、铜绿假单胞菌。MRSA的检出率为18.5%;大肠埃希菌和肺炎克雷伯菌产ESBLs比率分别为56.1%和47.3%;铜绿假单胞菌对碳青酶烯类的耐药率约30%,对其他监测抗菌药物的耐药率均<30%;鲍曼不动杆菌耐药率总体高于铜绿假单胞菌。结论本地区的细菌耐药性水平与全国及其他地区存在一定的差异。
Objective To monitor bacterial resistance,characteristics and development in rational drug use.Methods All bacteria susceptibility tests from 4 hospitals in Quanzhou from Jan 1st to Dec 31st in 2010 were monitored,and the data were analyzed by software WHONET 5.5.Results A total of 4 160 bacteria were isolated,including 2 625(63.1%)gram-negative strains and 1 535(36.9%)gram-positive strains.Escherichia coli,Klebsiella pneumoniae,Staphylococcus aureus,Acinetobacter baumannii and Pseudomonas aeruginosa were the most common bacteria.The incidence of meticillin-resistant Staphylococcus aureus was 18.5%.About 56.1% Escherichia coli and 47.3% Klebsiella pneumoniae produced extended spectrum-β-lactamases.The drug resistance rate of Pseudomonas aeruginosa strains to carbapenems was about 30%,and that to other antimicrobial agents was less than 30%.The drug resistance rate of Acinetobacter baumannii was higher than that of Pseudomonas aeruginosa.Conclusion There is difference in bacterial resistance in this region compared with other regions in China.
出处
《中南药学》
CAS
2012年第3期238-240,共3页
Central South Pharmacy
基金
泉州市科技局重点项目(编号:Z[2011]0165)
关键词
细菌
耐药性
抗菌药物
监测
bacterium
drug resistance
antimicrobial agent
surveillance