泉州市细菌耐药监测网重点医院细菌耐药性监测研究

Surveillance of bacterial resistance in Quanzhou key hospitals

目的监测细菌耐药性,依据细菌耐药状况、特点及发展趋势,指导临床用药。方法监测2010年度泉州地区4所重点医院临床分离细菌耐药状况,以WHONET 5.5软件进行数据分析。结果共分离得到致病菌4 160株,其中革兰阳性菌1 535株,占36.9%;革兰阴性菌2 625株,占63.1%。最常见的细菌依次为大肠埃希菌、肺炎克雷伯菌、金黄色葡萄球菌、鲍曼不动杆菌、铜绿假单胞菌。MRSA的检出率为18.5%;大肠埃希菌和肺炎克雷伯菌产ESBLs比率分别为56.1%和47.3%;铜绿假单胞菌对碳青酶烯类的耐药率约30%,对其他监测抗菌药物的耐药率均<30%;鲍曼不动杆菌耐药率总体高于铜绿假单胞菌。结论本地区的细菌耐药性水平与全国及其他地区存在一定的差异。

Objective To monitor bacterial resistance,characteristics and development in rational drug use.Methods All bacteria susceptibility tests from 4 hospitals in Quanzhou from Jan 1st to Dec 31st in 2010 were monitored,and the data were analyzed by software WHONET 5.5.Results A total of 4 160 bacteria were isolated,including 2 625（63.1%）gram-negative strains and 1 535（36.9%）gram-positive strains.Escherichia coli,Klebsiella pneumoniae,Staphylococcus aureus,Acinetobacter baumannii and Pseudomonas aeruginosa were the most common bacteria.The incidence of meticillin-resistant Staphylococcus aureus was 18.5%.About 56.1% Escherichia coli and 47.3% Klebsiella pneumoniae produced extended spectrum-β-lactamases.The drug resistance rate of Pseudomonas aeruginosa strains to carbapenems was about 30%,and that to other antimicrobial agents was less than 30%.The drug resistance rate of Acinetobacter baumannii was higher than that of Pseudomonas aeruginosa.Conclusion There is difference in bacterial resistance in this region compared with other regions in China.