中老年女性精神分裂症患者的血浆D-二聚体含量检测及其临床意义

Clinical significance of the plasma D-dimer in schizophrenia

目的 探讨血浆D 二聚体 (D dimer,DD)含量与精神分裂症之间的关系。方法 运用乳胶颗粒法对 31例中老年女性精神分裂症患者的血浆DD含量进行检测 ,并与 2 5名无精神疾病和脑血管病史的女性正常人 (对照组 )比较。结果 精神分裂症组的血浆DD含量 [(1 38± 1 0 2 )mg/L]高于对照组 [(0 6 1± 0 2 5 )mg/L],P <0 0 1。以阳性症状为主的精神分裂症患者的血浆DD含量[(1 91± 1 10 )mg/L]高于以阴性症状为主的患者 [(1 13± 0 82 )mg/L],P <0 0 5 ;且治疗后血浆DD含量 [(0 73± 0 2 9)mg/L]较治疗前降低 (P <0 0 5 )。结论 中老年女性精神分裂症患者血浆DD含量高于女性正常人 ,存在高凝状态和纤溶功能亢进。

Objective The goal of this study was to explore the relationship between schizophrenia and D dimer Methods The plasma D dimer levels were measured in 31 schizophrenics and 25 controls by latex grain method Results The plasma D dimer level in schizophrenia group was significantly higher than those in control group [ (1 38±1 02)mg/L and(0 61±0 25)mg/L, respective, P <0 01]; and that in positive symptom group [(1 91±1 10) mg/L] was higher than in negative symptom group [(1 13±0 82) mg/L; P <0 05] The plasma D dimer level in positive group was decreased markedly after treatment [(0 73±0 29)mg/L; P <0 05] Conclusions The hyperviscosity syndrome and hyperfunction of fibrin degradation can be occurred in the patients with schizophrenia The plasma D dimer level in schizophrenia was decreased along with the improvement of positive symptoms