大鼠应激性溃疡发病机理及防治研究

STUDY ON PATHOGENESIS AND TREATMENT OF STRESS ULCER IN RATS

目的 了解大鼠应激性溃疡与胃酸、前列腺素 (PGs)和促肾上腺皮质激素 (ACTH)水平彼此间的关系及其发病机理 ,并进行防治。方法 通过冷束缚法制成大鼠应激性溃疡模型 ,以东莨菪碱、地塞米松、雷尼替丁、洛赛克等药物进行应激性溃疡的防治 ,检测胃液量、pH值及胃粘膜的变化 ,测定PGs和ACTH的水平。结果 正常大鼠饥饿 2 4小时后抽到少量胃液 ;经冷束缚后 ,胃液量增加 ,pH值下降 ,胃粘膜出血 ,血中PGs下降 ,ACTH增加。提示在应激状态下 ,胃粘膜出血与胃液中 pH值下降、PGs含量下降和ACTH含量上升有关。 结论 防治应激性溃疡以升高胃液 pH值能达到目的 ;PGs升高对防治大鼠胃粘膜出血有明显作用 ;洛赛克提高胃液 pH值而不降低PGs的作用 ,可作为防治应激性溃疡的首选药。

Objective To investigate the relationship among rats′ stress ulcer and gastric acid, prostaglandin (PGs) and adrenocorticotropin (ACTH) and to probe the pathogenesis, prophylaxis and therapy. Methods Rats′ stress ulcer model was made by cold water soaking and was properly treated with drugs such as hyoscine, dexamethasone, ranitidine and losec. The amount and pH of gastric juice, change of gastric mucosa and PGs and ACTH of blood were determined. Results After rats were fasted for 24 hours a little gastric juice was aspirated. After cold water soaking of rats gastric juice was increased with the pH decreased, there was gastric mucosal bleeding, blood PGs was decreased and ACTH was increased. These suggest that on stress gastric mucosa bleeding is related with decreased gastric juice pH, decreased PGs and increase ACTH.Conclusion To control stress ulcer, pH of gastric juice and amount of PGs should be increased. Losec can increase gastric juice pH, so losec is the first choice to control stress ulcer.