nm23、CD44H和CD44V6蛋白在胃癌的表达及意义

EXPRESSION OF NM23, CD44H AND CD44V6 IN GASTRIC CARCINOMA AND ITS SIGNIFICANCE

目的 研究胃癌组织中nm2 3和CD44的表达 ,以及与淋巴结转移和预后的关系。方法 应用SP免疫组化技术对 10 5例胃癌组织nm 2 3、CD44H和CD44V6的表达进行观察 ,并对其中 5 9例患者随访。结果 nm2 3、CD44H及CD44V6蛋白表达阳性率分别为 44.8%、5 4.3 %和 48.6% ;nm2 3及CD44V6在胃癌组织的表达与其分化、浸润深度、临床分期和预后有关 ,而CD44H的表达与上述临床病理指标无关。 3种抗体的阳性反应与淋巴结转移有关 (nm 2 3P <0 .0 5 ;CD44V6P <0 .0 1;CD44HP <0 .0 5 )。结论 CD44H的表达可用于监测病情 ,而nm 2 3和CD44V6有希望作为一个判断预后的指标。

Objective To study the relationship between expression of nm23, CD44 in gastric carcinoma and lymph node metastasis and prognosis. Methods Expression of nm 23, CD44H and CD44V6 in 105 cases of gastric carcinoma were assayed by immunohistochemistry. Among them, 59 cases were followed up. Results The incidences of nm23, CD44H and CD44V6 protein positivity in gastric carcinoma were 44.8%, 54.3% and 48.6% respectively. The positive expression of nm23, CD44V6 protein in human gastric carcinoma tissues was related to the differentiation, depth of invasion, TNM stage and prognosis ( P <0.05), but expression of CD44H was not correlated with other clinicopathologic indices. The reactivity to these three antibodies were correlate with metastasis of lymph nodes (P<0.01 for CD44V6 and P<0.05 for nm23, CD44H). Conclusion Expression of the standard form of CD44 (CD44H) might be useful in observing the progression of the disease, wile CD44V6 and nm23 hold promise as a prognostic indicator.