直肠癌和大肠粘膜组织细胞间粘附分子-1的表达及其临床意义

EXPRESSION AND CLINICAL SIGNIFICANCE OF INTERCELLULAR ADHESION MOLECULES-1 IN RECTAL CARCINOMA AND COLON MUCOUS MEMBRANE TISSUE

目的 探讨细胞间粘附分子 1(CD5 4)在直肠癌组织和邻近肠粘膜组织的表达及临床意义。方法 应用荧光标记的CD5 4单克隆抗体分子探针 ,通过流式细胞仪检测 ,对 3 6例直肠癌癌组织、癌下缘 2cm处肠粘膜组织及患者正常结肠粘膜组织的CD5 4表达进行了对比研究。结果 直肠癌组织CD5 4表达阳性率为 9.79%± 5 .12 % ,与癌下缘 2cm处肠粘膜之差异无显著性意义 (P >0 .0 5 ) ,但显著高于正常结肠粘膜和对照组 (P <0 .0 5 )。结论 CD5 4在直肠癌组织中的高表达 ,可作为直肠癌临床研究的指标 ;癌下缘 2cm处肠粘膜CD5 4表达与直肠癌组织相似 ,有恶性转化的趋势。

Objective To investigate the expression of intercellular adhesion molecules-1 (CD54) in rectal carcinoma and nearby mucous membrane and its clinical significance. Methods The expression of CD54 in the tumors and the mucous membrane 2cm away from the lesions and on the colon section margin was comparatively studied by flow cytometry in 36 cases with rectal carcinoma. Results The CD54 expression of rectal carcinomas were 9.79%±5.12%, similar to that of the mucous membrance 2cm distal away from the lesions (P>0.05) and more than that of colon section margins and control group (P<0.05). Conclusion CD54 is highly expressed in both the rectal carcinoma and the mucous membrance 2cm distal away from the lesions. CD54 may be used as an important clinical tumor marker for rectal carcinoma and the mucous membrance 2cm away from the lesions may have the tendency for malignancy.