腹腔内化疗对胃肠道肿瘤的治疗

INTRAPERITONEAL CHEMOTHERAPY IN THE TREATMENT OF GASTROINTESTINAL MALIGNANCIES

目的 了解腹腔内化疗对消化道肿瘤的治疗价值。方法 采用文献检索方法对腹腔化疗在胃肠道肿瘤治疗的价值进行分析并加以综述。结果 腹腔注射化疗后 ,可以在腹腔液内及门静脉血里有较高、恒定和持久的抗癌药物浓度 ;术后早期给药最佳。Port A Cath可以提供一个方便的导管系统。腹腔化疗并发症少。结论 术后早期腹腔化疗方法可以提高腹腔内肿瘤的治疗效果 ,尤其可以预防或治疗术后复发和肝等远处器官的转移。

Objective To study the value of intraperitoneal chemotherapy in the treatment of gastrointestinal malignancies. [WT5”HZ]Methods [WT5”BZ]The current literature on intraperitoneal chemotherapy was reviewed. [WT5”HZ]Results [WT5”BZ]Following intraperitoneal injection, the concentration of drugs in the peritoneum and in the portal vein was high, lasting and sustained. Early post operative chemotherapy showed better results. Port A Cath provides a safe and suitable drug delivery system. Complications were mild. [WT5”HZ]Conclusion [WT5”BZ]Intraperitoneal chemotherapy presents significant pharmacokinetic and clinical potentials in the treatment of gastrointestinal malignancies, as well as in the prevention and treatment of postoperative metastasis.