尿道灌注治疗衣原体和脲原体性尿道炎

Therapy of urethral infusion of the urethritis caused by chlamydia trachomatis or/and ureaplasm urealyticum

目的 :探讨乳糖红霉素和地塞米松尿道灌注治疗沙眼衣原体 (CT)和 (或 )解脲脲原体 (UU )性尿道炎的疗效。方法 :筛选出 15 0例不并发淋病、附睾炎及前列腺炎 ,有尿道炎症状 ,尿道分泌物荧光聚合酶链反应检查CT和 (或 ) U U阳性病例 ,随机分为 3组 ,每组各 5 0例。服药组 ,口服福爱力红霉素 ;灌注组 ,用 1%乳糖红霉素和0 .5 %地塞米松作尿道灌注 ;对照组 ,尿道灌注生理盐水。10 d为 1个疗程。结果 :经过 1～ 2个疗程治疗 ,服药组治愈 31例 ,好转 4例 ,无效 15例 ;灌注组治愈 41例 ,好转 5例 ,无效 4例 ;对照组治愈 4例 ,好转 2例 ,无效 44例。结论 :尿道灌注治疗明显优于口服药物治疗 (P <0 .0 5 ) ,且无明显不良反应。

Purpose:To evaluate the effects of urethral infusion with erythromycin and steroid for treatment of the male urethritis caused by chlamydia trachomatis (CT) or/and ureaplasm urealyticum (UU).Methods:150 patients with the symptom of ureathritis,the examination of urethral discharge CT or/and UU (FQ PCR) being positive without being complicated by gonorrhea,epididymitis,prostatitis were chosen. All 150 patients were divided at random into 3 groups. Each group contained 50 patients.Group 1——Taking drugs,the patients took erythromycin (Faulding Pharmaceuticals) orally;Group 2——Urethral infusion,the patients were infused with 1% erythomycin lactobionate and 0.5 % dexamethasoni natrii phosphatis into their urethrae;Group 3——Control,the patients were infused with normal saline for 10 days as a course.Results:All the patients experienced the treatment for one or two courses with the results:Group 1,31 cases were cured,4 cases improved,15 cases failure;Group 2,41 cases were cured,5 cases improved,4 cases failure;Group 3,4 cases were cured,2 cases improved,44 cases failure.Conclusions:The treatment of urethral infusion with erythromycin and steroid had more effective than that of taking drugs orally (P< 0.05 ) and much more effective than that of the control group (P< 0.005 ). And this method had less harmful effects.