前列腺炎对血清PSA浓度的影响

Effect of prostatitis on serum prostate specific antigen levels

目的 :探讨前列腺炎对血清 PSA浓度的影响。方法 :选择 48例 2 1～ 40岁的前列腺炎患者 ,用 EL ISA法测定直肠指检前的血清 PSA浓度 ,与正常组 2 1例对照 ,并对比治疗前后血清 PSA浓度的变化。结果 :前列腺炎组和对照组的血清 PSA浓度分别为 (1.5± 0 .4)和 (0 .4± 0 .2 ) μg/ L,两组间有极显著性差异 (t=11.96 ,P<0 .0 0 1) ;31例治疗有效者 ,治疗后血清 PSA浓度较治疗前明显下降 (P <0 .0 0 1) ,而 12例无效者 ,血清 PSA浓度较治疗前下降不明显 (P >0 .0 5 )。结论 :前列腺炎时血清 PSA浓度明显升高 ,但随着炎症的消失 ,PSA浓度可逐渐恢复正常。

Purpose:To study the effect of prostatitis on the concentration of serum prostate specific antigen(PSA) elevation. Methods:The serum PSA concentrations were measured in 48 young men(mean age 28.8 ± 5.3 years) who had clinical symptoms of prostatitis and positive results of microscopic examination on expressed prostatic secretion ,and were compared with those of 21 men who were at the same age grade and had no symptoms of prostatitis or other urinary system diseases. The PSA concentrations measured before and after therapies in the study group were also compared.Results:The mean concentration of serum PSA in prostatitis group and control group were ( 1.5 ± 0.4 ) and ( 0.4 ± 0.2 ) μg/L respectively. The difference between the PSA concentrations of those two groups was significant (t= 11.96 ,P< 0.001 ). The serum PSA concentrations of those 31 patients who had an effective therapy results had reduced significantly after the course of treatment(P< 0.001 ), while those of the 12 patients who had no effective curative results had reduced insignificantly(P> 0.05 ).Conclusions:Prostatitis can elevate serum PSA significantly. But this elevation will gradually decrease to the normal levels after the inflammation is counteracted.