摘要
目的研究子宫内膜异位症患者子宫在位内膜和异位内膜的IL-18表达,探讨IL-18在内异症发病机制中的意义。方法用免疫组织化学方法检测正常人子宫内膜和内异症患者的子宫在位内膜与异位内膜的IL-18表达。结果 IL-18的免疫组化结果均有表达,主要表达于子宫的上皮细胞,基质细胞也有表达,但是较弱。IL-18对照组子宫内膜标本阳性的灰度值高于内异症子宫在位内膜组而内异症异位灶组织阳性的灰度值最低,和对照组以及内异症在位内膜组相比差异均有统计学意义(P<0.05)。结论 IL-18在内异症患者在位和异位内膜的异常表达,可能是影响内异症形成和发展的重要因素之一。
Objective 10 study of expression of IL-18 in eutopic and ectpic endometrium of endometrio- sis and the role on the pathogenesis of this disease. Methods The expression of IL-18 in endometrinsis patients was detected by immunohistochemistry methods. Results IL-18 protein was found in all specimens and the ex- pression of IL-18 in ectopic and eutopic endometrium from patients with endometriosis was significantly lower than that of normal women endometrium （ P 〈0. 05 ）. Conclusion Women with endometriosis show down regulation of IL-18 expression in ectopic and eutopic endometrium, may be one of the pathogenesis of endometriosis.
出处
《中国实用医药》
2012年第5期48-49,共2页
China Practical Medicine
