摘要
目的观察纳美芬对脑梗死患者血清细胞因子(IL-8、TNF-α、IL-6)炎性细胞因子影响评价脑梗死患者的治疗作用。以期为临床工作提供理论帮助。方法选择在我院住院诊治的100例脑梗死患者,随机分为两组,治疗组共50例在常规治疗基础上加用纳美芬治疗,对照组共50例常规治疗;两组患者均于治疗前及治疗后留取静脉血,应用酶联免疫吸附实验(ELISA)检测血清中(IL-8、TNF-α、IL-6)的表达,观察纳美芬对两组患者的疗效及对血清中(IL-8、TNF-α、IL-6)表达的影响。结果治疗组总有效率明显高于对照组,治疗组与对照组治疗后比较(IL-8、TNF-α、IL-6)明显下降。结论纳美芬能明显降低血清中(IL-8、TNF-α、IL-6)的表达,对脑梗死患者有明显治疗作用。
Objective To investigate the influence of nalmefene on the level of TNF-α, IL-6, IL-8 in the patients with acute cerebral infarction disease. Methods The patients were randomly divided into two groups. The treatment group took nalmefene and the control group. The changes of serum cytokines （ TNF-a, IL- 6, IL-8 ） were observed before and after the treatment. Results After the treatment,both groups suppressed on the expression of TNF-a, IL-6, IL-8. The treatment group was superior to the control one. Conclusion Nalmefene can suppress expression of TNF-a, IL-6, IL-8 ,and have therapy effection.
出处
《中国实用医药》
2012年第5期54-56,共3页
China Practical Medicine
