输血传播病毒母婴感染的前瞻性研究

A Clinical Prospective Study on Maternal-fetal Transfusion Transmitted Virus Infection

目的 探讨孕产妇输血传播病毒 (TTV)感染率及其在母婴间的传播途径。方法 应用巢式聚合酶链反应 (n PCR)技术检测 6 0例健康孕产妇 (观察组 )静脉血TTV ,并对TTV阳性产妇的乳汁及其新生儿脐血进行检测。并以 2 5 1例健康非孕妇女 (对照组 )的TTV感染情况作对照。结果 观察组TTV感染率为 2 8.33% ,对照组TTV感染率为 7.5 7% ,两组比较差异有非常显著性 (P <0 .0 0 1)。观察组中TTV阳性产妇乳汁TTV检出率为 2 7.2 7% ,其新生儿脐血未检出TTV。结论 孕产妇TTV感染率较高 ,TTV可能通过乳汁感染新生儿 ,但母婴间不存在垂直传播关系。

Objective To observe the transfusion transmitted virus (TTV) infection rate in gravidas and parturients,and explore the route of maternal fetal transmission. Methods TTV infection was detected by nest polymerase chain reaction (n PCR) in the serum of 60 healthy gravidas and parturientes. Once parturient infection was identified, the latices and the umbilical blood were examined for TTV infection as well. Meanwhile, a group of non pregnant healthy women was tested as control. Results The infection rate of observation group was 28.33%, while in the control group it was 7.57%. The difference of the two groups was significant ( P <0.001). Of the TTV positive parturientes, TTV infection rate of their latices was 27.27%, but none of the umbilical blood samples showed TTV positive. Conclusions The TTV infection rate of gravidas and parturientes is higher than that of non pregnant healthy women. TTV can infect newborns through latices, however, there is no vertical maternal fetal transmission.