妊娠高血压综合征患者的新生儿脐血内皮素和一氧化氮的变化

Changes of Endotheliolysin and Nitric Oxide in Newborns' Cord Blood of the Pregnant Women with Pregnancy Induced Hypertension

目的 探讨内皮素 ( ET)和一氧化氮 ( NO)在妊娠高血压综合征 ( PIH)患者的新生儿脐血的变化。方法 使用放免法测定 ET;采用硝酸根还原酶法结合 Griess试剂测定 NO的稳定代谢产物亚硝酸基 ( NO- 2 )和硝酸基 ( NO- 3)的含量。对 2 1例 PIH患者的新生儿和 2 4例健康孕妇的正常新生儿脐血进行了测定。结果 中、重度 PIH患者新生儿脐血 ET显著高于对照组 ,而 NO- 2 和 NO- 3含量显著低于对照组 ( P<0 .0 5 )。中、重度 PIH并发胎儿宫内发育迟缓 ( IUGR)者脐血 ET显著高于未并发 IUGR组 ( P<0 .0 1) ,而NO- 2 和 NO- 3显著低于未并发 IUGR者 ( P<0 .0 5 )。结论 ET升高 ,NO降低可能是 IUGR发生的重要环节。

Objective To study the changes of ET and NO in newborns' cord blood of the pregnant women with PIH. Methods ET was detected by means of radioactive immunity; the expression of NO - 2 and NO - 3 ,which are the constant metabolism products , were determined by using the combination of nitric reductase and Griess reagent. The newborns' cord blood of 21 with PIH and that of 24 healthy pregnant women were detected. Results The expression of ET in newborns' cord blood of moderate and severe PIH is significantly higher than that of the control group, while the expression of NO - 2 and NO - 3 is remarkably lower than that of the control group.(P<0.05). The expression of ET in newborns' cord blood of moderate and severe PIH complicated with IUGR is remarkably higher than that of PIH with no complication of IUGR.(P<0.01) while NO - 2and NO - 3are significantly lower than that of PIH with no complication of IUGR.(P<0.05). Conclusion: The increased expression of ET and the reduced expression of NO may be the key signals of IUGR incidence.