天冬氨酸家族主要氨基酸高产菌株的选育策略

Metabolic Engineering Strategies of Bacterial Strains for Overproduction of L-Threonine and L-Lysine

L-苏氨酸与L-赖氨酸是L-天冬氨酸家族氨基酸(AFAAs)中的重要成员,近年来由于其在食品、化妆品、动物饲料添加剂等方面的广泛应用而备受关注,市场需求逐年上升。运用代谢工程手段构建高产菌,可有效地提高L-苏氨酸和L-赖氨酸的生产水平。本文详述了L-苏氨酸与L-赖氨酸的合成途径、调控机制以及两种氨基酸高产菌株的构建策略。

L-Threonine and L-lysine,two of the L-aspartate family amino acids（AFAAs）,have attracted great attention because of their wide application in industries of food,animal feeding and cosmetics.Metabolic engineering of bacterial strains significantly improved the production of L-threonine and L-lysine.Here,biosynthetic pathways and regulations of L-threonine and L-lysine are summarized.The strategies of metabolic engineering for the development of L-threonine and L-lysine overproducers are also discussed.