感染性疾病中血清降钙素原和C反应蛋白检测的临床意义

The clinical significance of serum procalcitonin and C-restive protein in diagnosis of infection disease

目的分析感染性疾病中血清降钙素原（PCT）和C反应蛋白（CRP）的临床意义。方法检测200例感染性疾病及80例非感染性疾病患者血清中的PCT和CRP含量。结果治疗前细菌感染组120例患者PCT测定值为（23．3±7．8）μg／L，CRP为（26．7±17．1）mg／L；治疗后PCT为（2．1±0．7）μg／L，CRP为（4．9±0．9）mg／L，治疗前后差异有显著性（P〈0．01）。细菌感染组和病毒感染组、非感染组比较差异有显著性（P〈0．01）。结论在感染时，PCT和CRP检测对于疾病的鉴别与诊断有很大的作用，对其进行动态检测对于疗效判断有一定的临床意义与价值。

Objective To explore the clinical significance of serum procalcitonin （ PCT ） and C-reactive protein（ CRP ） in the diagnosis of infection disease. Methods Serum PCT and CRP results were analyzed in 200 patients with infection disease and 80 patients with no-infection disease. Results Serum PCT of 120 patients with bacterium infection before and after treatment were（ 23.3 ±7.8）μ/L and （2.1 ±0.7）μ g/L, respectively; and serum CRPwere （26.7 ± 17.1 ） mg/Land （4.9 ± 0.9） mg/L; serum PCT and CRP of the patients with bacterium infection after treatment significantly differed from that before treatment （ P 〈 0.01 ）. Serum PCT and CRP of patients with bacterium infection was significantly higher than that of patients with virus infection or no infection （ P 〈 0.01 ）. Conclusions During infection, the combination test of PCT and CRP play an important role on the differentiation and diagnosis of diseases. Dynamically testing them has some certain clinical significance and value in the assessment of curative efficacy.