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N-苄氧羰基-甘氨酸水飞蓟宾单酯的合成及其抗氧化活性 被引量：2

Synthesis and Antioxidant Activities of Silybin Ester of N-Carbobenzyloxyglycine
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摘要 以水飞蓟宾(1)与N-苄氧羰基-甘氨酸为起始原料,采用DCC/DMAP促进偶合法合成了新型的N-苄氧羰基-甘氨酸-3-水飞蓟宾酯(2),其结构经UV,1H NMR,IR和ESI-MS表征。采用化学和生物学模型考察了2的清除自由基能力和抗脂质过氧化能力。结果表明,在测定浓度范围内,2具有较好的清除自由基能力和抗脂质过氧化能力。 A novel silybin ester of N-carbobenzyloxyglycine（2） was synthesized by DCC/DMAP cou- pling method by silybin （1） and N-carbobenzyloxyglycine. The structure was characterized by UV, H NMR, IR and ESI-MS. The abilities of free radical scavenging and anti-lipid pcroxidation were in- vestigated by chemical and biological assays. The results showed that 2 exhibited good free radical scavenging and anti-lipid peroxidation at detecting concentration.
作者 刘伟 许宾宾 曹树稳
机构地区 伊犁师范学院化学与生物科学学院 南昌大学食品科学与技术国家重点实验室
出处 《合成化学》 CAS CSCD 北大核心 2012年第2期220-222,共3页 Chinese Journal of Synthetic Chemistry
关键词 水飞蓟宾 合成 抗氧化活性 silybin synthesis antioxidant activity
分类号 O621.3 [理学—有机化学]
  • 相关文献

参考文献9

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共引文献6

同被引文献26

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二级引证文献9

合成化学
2012年 第2期

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