椿皮化学成分的研究

Chemical constituents from barks of Ailanthus altissima

目的研究椿皮的化学成分。方法采用硅胶、凝胶、ODS及RP-HPLC对椿皮化学成分进行分离纯化,并根据理化性质和波谱数据鉴定化合物的结构。结果从椿皮95%乙醇提取物中分离得到12个化合物,分别鉴定为erythro-guaiacylglycerol-β-O-4′-coniferyl ether(1)、threo-guaiacylglycerol-β-O-4′-sinapyl ether(2)、threo-guaiacylglycerol-β-O-4′-dihydroconiferyl ether(3)、咖啡酸甲酯(4)、松柏苷(5)、scopoletin(6)、7-methoxy-2H-chromene(7)、香草醛(8)、4-hydroxy-2(E)-nonenoic acid(9)、(9S,12S,13S)-(E)-9,12,13-trihydroxy-10-octadecaenoic acid(10)、β-谷甾醇(11)和胡萝卜苷(12)。结论化合物1～5、7、9和10为首次从该属植物中分离得到。

Objective To investigate the chemical constituents in the barks of Ailanthus altissima.Methods The chemical consituents were isolated by silica gel,Sephadex LH-20,ODS,as well as RP-HPLC column chromatographies.Their structures were identified on the basis of physicochemical properties and spectral analysis.Results Twelve compounds were isolated and idenified as erythro-guaiacylglycerol-β-O-4′-coniferyl ether（1）,threo-guaiacylglycerol-β-O-4′-sinapyl ether（2）,threo-guaiacylglycerol-β-O-4′dihydroconiferyl ether（3）,caffeic acid methyl ester（4）,coniferin（5）,scopoletin（6）,7-methoxy-2H-chromene（7）,vanillin（8）,4-hydroxy-2（E）-nonenoic acid（9）,（9S,12S,13S）-（E）-9,12,13-trihydroxy-10-octadecaenoic acid（10）,β-sitosterol（11）,and daucosterol（12）,respectively.Conclusion Compounds 1—5,7,9,and 10 are isolated from this plant for the first time.