清脂康胰联针穴位注射治疗2型糖尿病的疗效观察

Clinical effects of Qingzhikangyi acupuncture point injection on type 2 diabetes mellitus diagnosed on the first visit

目的探讨清脂康胰联针穴位注射治疗2型糖尿病的疗效。方法经知情同意,将120例门诊2型糖尿病患者分为穴位组和对照组,穴位组90例用清脂康胰联针(复方丹参注射液、盐酸川芎嗪注射液、板兰根注射液、穿心莲注射液、舒血宁注射液、脉络宁注射液)穴位注射。对照组30例不使用清脂康胰联针穴位注射。2组患者均给予血脂康胶囊、益肝灵片、维生素E、二甲双胍片等药物治疗。结果穴位组治愈84例,有效4例,无效2例;对照组治愈5例,有效6例,无效19例。穴位组治愈率93.3%,总有效率97.8%,明显优于对照组(治愈率16.2%,总有效率36.25%)(P<0.01)。2组患者经过4个月治疗后,穴位组体质量指数(BMI)、白细胞计数(WC)、收缩压、舒张压、糖化血红蛋白(HbAlc)、胰岛素抵抗指数(HOMA-IR)、中心性肥胖、血脂、血压、脂肪肝治疗后与治疗前及与对照组治疗后比较,差异均有统计学意义(P<0.01)。2组总胆固醇(TC)、三酰甘油(TG)治疗后与治疗前比较,差异均有显著性(P<0.01)。穴位组各时间点口服葡萄糖耐量试验(OGTT)血糖值治疗后与治疗前及与对照组治疗后比较,差异均有统计学意义(P<0.01)。穴位组OGTT 0 min胰岛素值治疗后与治疗前比较有下降,差异有统计学意义(P<0.05)。穴位组30 min胰岛素值治疗后与治疗前及对照组治疗后比较有显著上升,差异均有统计学意义(P<0.01)。穴位组60、120 min胰岛素值治疗后与治疗前及对照组治疗后比较有下降,差异均有显著性(P<0.01)。穴位组ΔI30/ΔG30、B细胞功能指数(HOMAB)治疗后与治疗前及对照组治疗后比较差异显著(P<0.01)。穴位组B细胞功能指数(MBCI)治疗后与治疗前比较差异显著(P<0.05)。结论采用清脂康胰联针穴位注射治疗初诊2型糖尿病的疗效,明显优于单用祛脂降糖等药物的疗效。

Objective To investigate the clinical effects of Qingzhikangyi(a preparation having the function of lipid-lowering and pancreas-protecting) acupuncture point injection on type 2 diabetes mellitus,which was diagnosed on the first visit.Methods Ninety cases in the point injection group were injected with Qingzhikangyi solutions(compound Danshen,hydrochloric Ligustrazine,Banlangen,Chuanxinlian,Shuxuening and Mailuoning) in acupuncture points.Thirty cases in the control group did not have Qingzhikangyi acupuncture point injection.Patients in both groups were given Xuezhikang capsules,Yiganling tablets,vitamin E and metformin tablets.Results In the point injection groups,84 cases were cured,4 cases were effective and 2 cases ineffective.In the control group,5 cases were cured,6 cases were effective and 19 ineffective.For the former group,the cure rate was 93.3% and total effective rate 97.8%,which was obviously superior to those of the control group with the cure rate and total effective rate being 16.2% and 36.25% respectively.After 4 months of treatment for the 2 groups,significant differences could be seen in body mass indexes(BMI),white cell counts(WC),systolic pressure,diastolic pressure,glycosylated hemoglobin collection(HbAlc),HOMA-IR,visceral obesity,lipid,blood pressure,fatty liver in the point injection group,when comparisons were made between post-treatment and pre-treatment,and also when they were compared with those of the control group after treatment,all with statistical significance(P<0.01).Significant differences could be seen in total cholesterol(TC) and trigeminal ganglion(TG),when comparisons were made between pre-treatment and post-treatment(P<0.01).In the oral glucose tolerance test(OGTT) for the point injection group,statistical significance could be noticed in blood glucose values at various time points,when comparisons were made between pre-treatment and post-treatment,and also when they were compared with those of the control group after treatment,all with statistical significance(P<0.01).0-min insulin value in OGTT for the injection group decreased,when comparisons were made between post-treatment and pre-treatment,with statistical significance(P<0.05).After 30-min treatment,significant increase in insulin values could be noted in the injection group,when comparisons were made between post-treatment and pre-treatment,and also when they were compared with those of the control group after treatment,all having statistical significance(P<0.01).After 60-min and 120-min treatment,there was a decrease in insulin values for the injection group,when comparisons were made between post-treatment and pre-treatment,and also when they were compared with those of the control group after treatment,all with statistical significance(P<0.01).Significant differences in ΔI30/ΔG30 and HOMAB could be noticed in the injection group,when comparisons were made between post-treatment and pre-treatment,and also when they were compared with those of the control group after treatment,all having statistical significance(P<0.01).Significant differences could also be seen in MBCI for the injection group,when comparisons were made between post-treatment and pre-treatment(P<0.05).Conclusion The therapeutic effects of Qingzhikangyi point injection on type 2 diabetes mellitus treated on first visit were obviously superior to those by simply using the drugs with the function of eliminating lipid and reducing blood glucose.