摘要
以4-哌啶酮盐酸盐为原料,经过Cbz保护、卡宾插入、脱除酯基,合成氮杂环庚酮,总收率87%,其结构经过1H NMR和MS表征。
Aza-cycloheptanone was synthesized from 4-piperidone monohydrate hydrochloride by three-steps reaction of protection,Schimit reaction and deesterification.The total yield was 88%,the structure was characterized by 1H NMR and MS.
出处
《应用化工》
CAS
CSCD
2012年第3期546-547,共2页
Applied Chemical Industry
关键词
氮杂环庚酮
卡宾
合成
aza-cycloheptanone
carbene
synthesis