良恶性胸腔积液的病理细胞学、癌胚抗原和铁蛋白检测的对比性研究

Comparative study of detection of cytopathology,CEA and FT in benign and malignant pleural effusion

目的对良恶性胸腔积液(胸液)病理细胞学、癌胚抗原(CEA)和铁蛋白(FT)检测进行对比研究。方法比较分析48例癌性胸液和32例结核性胸液的临床表现、影像学表现、血清及胸液CEA、FT测定结果。结果 48例癌性胸液为血性40例,32例结核性胸液为血性8例,恶性胸液CEA、FT比其血清CEA、FT明显升高(P<0.05),同结核性胸液比也较之升高(P<0.05)。结论病理细胞学检查可确诊癌性胸液,CEA、FT检测可以提高该病的检出率。

Objective To investigate the ways of cytopathology,CEA and FT in diagnosing benign and malignant pleural effusion.Methods 48 cases diagnosed as malignant pleural effusion and 32 cases of benign pleural effusion were reviewed and compared by clinical observations,chest X-ray and CT,level of CEA and FT in pleural effusion and serum.Results 40 of 48 cases diagnosed as malignant pleural effusion and 8 of 32 as benign pleural effusion were bloody pleural fluid.The levels of CEA and FT in malignant pleural effusion were significantly higher than those in serum（P0.05）,and higher than those in tuberculosis pleural effusion（P0.05）.Conclusions Cytopathology can make a confirmed diagnosis of malignant pleural effusion.Evaluation of CEA and FT in pleural effusion can improve the differential diagnosis of malignant pleural effusion from benign pleural effusion and significantly increase the sensitivity of diagnosis.