MCI和AD患者血清hs-CRP、Hcy水平研究

Levels of high sensitivity C-reactive protein and homocysteine in MCI and AD patients

目的研究轻度认知功能障碍(MCI)与阿尔茨海默病(AD)患者血清超敏C-反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)的变化,探讨炎症及血管因素在AD临床诊断和治疗中所起的作用。方法依据美国DSM-IV诊断标准,将研究对象分为健康对照组、MCI组和AD组;hs-CRP检测采用免疫透射比浊法,Hcy检测采用酶循环法。结果 AD组hs-CRP水平为(0.92±0.88)mg/L,与健康对照组的(2.24±1.34)mg/L及MCI组的(11.25±3.73)mg/L相比明显降低,差异有统计学意义(P<0.05),MCI组与健康对照组相比则明显升高(P<0.05);AD组Hcy水平为(18.53±7.06)μmol/L,与健康对照组的(14.36±4.86)μmol/L及MCI组的(15.22±5.90)μmol/L相比明显升高,差异有统计学意义(P<0.05),MCI组与健康对照组相比无明显变化(P>0.05)。结论炎症以及血管因素在AD的临床诊断和治疗中具有重要意义。

Objective To study the level of high sensitivity C-reactive protein（hs-CRP） and homocysteine（Hcy） in MCI and AD patients, and to evaluate the use of inflammatory and vascular factors in the clinical diagnosis and treatment of AD. Methods Based on the U.S. DSM-IV diagnosis standard, normal healthy control subjects and patients with MCI or AD disease were examined for the levels of high hs-CRP by Immune turbidimetric method.Hcy was detected by enzymatic method. Results The level of hs-CRP in the AD group was lower（P0.05） than the control and MCI group. The level of hs-CRP in the MCI group was higher （P0.05） than the control group. The level of Hcy in the AD group was obviously higher （P0.05） than the control and MCI group. There was no significant different in the level of Hcy between the MCI and control group（P0.05）. Conclusion Inflammation and vascular factors may be used in the clinical diagnosis and the development of treatment of AD.