某地区女性泌尿生殖道感染患者人乳头瘤病毒感染现状调查

Analysis of HPV infection in women with genitourinary tract infection in certain area

目的研究该地区女性泌尿生殖道感染患者人乳头瘤病毒(HPV)感染状况及HPV阳性患者HPV基因型分布状况,确定该地区HPV感染的优势型别。方法采用基因芯片技术对591例女性泌尿生殖道感染患者进行HPV检测。结果检出HPV阳性者288例,检出率为48.73%;低危型感染116例,占40.28%,高危型141例,占48.96%,混合型感染31例,占10.76%;低危型感染以HPV6、11型为主,分别占48.28%、42.24%;高危型感染以HPV16型为主,占43.26%。HPV易感年龄阶段为20～<40岁,占所有感染者的63.54%。结论该地区女性泌尿生殖道感染患者HPV感染率较高,以高危型感染为主,且存在与低危型混合感染的可能。

Objective To study infection status of human papillomavirus （HPV） in women with genitourinary tract infection（GTI） and the distribution of HPV genotype to confirm the dominant genotype of HPV infection in this area.Methods Hybrid technology was used for the detection of HPV in 591 cases of women with GTI.Results The positive rate of HPV was 48.73%（288/591）,including 116 cases（40.28%） of low risk genotype,141 cases（48.96%） of high risk genotype and 31 cases（10.76%） of mixed infection.In low risk genotype,mainly were HPV6 or 11,48.28% and 42.24% for each.In high risk genotype,mainly was HPV16,occupying 43.26%.The age of 21-40 years old was the highest proportion of HPV infection,accounting for 63.54% of all infected persons.Conclusion In this area,HPV infection rate was high in women with GTI,mainly of which were caused by high risk genotype and there might be mixed infections of low and high risk genotype.