胃癌患者血清血管内皮生长因子和生存素水平检测及临床意义分析

Significance analysis of vascular endothelial growth factor and Survivin in patients with gastric carcinoma

目的探讨胃癌患者血清血管内皮生长因子(VEGF)和生存素(Survivin)水平变化规律及其临床意义。方法酶联免疫吸附法检测136例确诊胃癌患者(观察组)和136例健康成人(对照组)血清VEGF和Survivin水平,并分析其相关性。结果观察组血清VEGF和Survivin水平高于对照组(P<0.05);血清VEGF和Survivin水平与胃癌分化程度及淋巴结转移密切相关(P<0.05);胃癌患者血清VEGF和Survivin水平呈正相关(P<0.05)。结论胃癌患者血清VEGF和Survivin水平异常升高,二者可能在胃癌发生、发展中具有重要作用;早期联合检测VEGF和Survivin可能对患者预后判断及指导临床治疗有重要价值。

Objective To explore the changes and clinical significance of serum vascular endothelial growth factor（VEGF） and Survivin in patients with gastric carcinoma.Methods Enzyme linked immunosorbent assay was performed for the detection of serum VEGF and Survivin in 136 cases of patients with gastric carcinoma（observation group） and 136 cases of healthy controls（control group）,and the correlation was also analyzed.Results Serum levels of VEGF and Survivin were significantly higher in observation group than those in control group（P0.05）.Serum levels of VGEF and Survivin were closely correlated with the differentiation and lymphonode metastasis of gastric carcinoma（P0.05）.In patients with gastric carcinoma,there was positive correlation between serum levels of VEGF and Survivin.Conclusion Higher expression of VEGF and Survivin could be related with the carcinogenesis and development of gastric carcinoma.Early and combined detection of VEGF and Survivin could be helpful to predict the prognosis and direct treatment in gastric carcinoma.